Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate

Jue Wang,1 Fen Wei Wang2 1Department of Internal Medicine, Oncology-Hematology Division, University of Nebraska Medical Center, 2Department of Internal Medicine, Creighton University Medical School, Omaha, NE, USA Background: The effects of age on clinical presentation, treatment, and outcomes for...

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Autores principales:	Wang J, Wang FW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Small-cell carcinoma of the prostate (SCCP) Surveillance Epidemiology and End Results (SEER) Program database Radical prostatectomy Cancer-specific survival Age. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/cdfb7b9483314fc4beb7cf399011f9af
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spelling	oai:doaj.org-article:cdfb7b9483314fc4beb7cf399011f9af2021-12-02T03:28:28ZImpact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate1178-1998https://doaj.org/article/cdfb7b9483314fc4beb7cf399011f9af2013-07-01T00:00:00Zhttps://www.dovepress.com/impact-of-age-on-clinical-presentation-treatment-and-cancer-specific-s-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jue Wang,1 Fen Wei Wang2 1Department of Internal Medicine, Oncology-Hematology Division, University of Nebraska Medical Center, 2Department of Internal Medicine, Creighton University Medical School, Omaha, NE, USA Background: The effects of age on clinical presentation, treatment, and outcomes for patients with small-cell carcinoma of the prostate (SCCP) are unclear. Methods: A retrospective review was performed on 259 patients who were identified with SCCP in the national Surveillance, Epidemiology, and End Results (SEER) registry from January 1973 to December 2004. The patients were categorized into two groups according to age at diagnosis, ie, younger than 75 years (n = 158, 61%) or 75 years and older (n = 101, 39%). Patient and treatment characteristics and cancer-specific survival were compared between the groups. Multivariate analysis was performed to identify independent prognostic factors associated with cancer-specific survival. Results: The median age of the patients was 72 (30–95) years. There was no significant difference in terms of tumor characteristics, concomitant adenocarcinoma grade, SEER stage, and treatment (including prostatectomy and radiation therapy) received between the groups. Median cancer-specific survival was 19 months (95% confidence interval 13–25). By multivariate Cox proportional hazard modeling, older age group (hazard ratio [HR] 1.95; P = 0.001), concomitant high-grade adenocarcinoma (HR 7.13; P = 0.007), and not having prostatectomy (HR 3.77; P = 0.005) were found to be significant independent predictors of poor cancer-specific survival. Conclusion: Older patients with SCCP had increased risk of poor cancer-specific survival. Whether this age-related poor outcome can be attributed to more aggressive tumor biology in older patients, or is simply a reflection of age-related poor performance status and suboptimal chemotherapy needs further investigation. Keywords: small-cell carcinoma, prostate, radical prostatectomy, radiation, cancer-specific survival, ageWang JWang FWDove Medical PressarticleSmall-cell carcinoma of the prostate (SCCP)SurveillanceEpidemiologyand End Results (SEER) Program databaseRadical prostatectomyCancer-specific survivalAge.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 871-877 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Small-cell carcinoma of the prostate (SCCP) Surveillance Epidemiology and End Results (SEER) Program database Radical prostatectomy Cancer-specific survival Age. Geriatrics RC952-954.6
spellingShingle	Small-cell carcinoma of the prostate (SCCP) Surveillance Epidemiology and End Results (SEER) Program database Radical prostatectomy Cancer-specific survival Age. Geriatrics RC952-954.6 Wang J Wang FW Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate
description	Jue Wang,1 Fen Wei Wang2 1Department of Internal Medicine, Oncology-Hematology Division, University of Nebraska Medical Center, 2Department of Internal Medicine, Creighton University Medical School, Omaha, NE, USA Background: The effects of age on clinical presentation, treatment, and outcomes for patients with small-cell carcinoma of the prostate (SCCP) are unclear. Methods: A retrospective review was performed on 259 patients who were identified with SCCP in the national Surveillance, Epidemiology, and End Results (SEER) registry from January 1973 to December 2004. The patients were categorized into two groups according to age at diagnosis, ie, younger than 75 years (n = 158, 61%) or 75 years and older (n = 101, 39%). Patient and treatment characteristics and cancer-specific survival were compared between the groups. Multivariate analysis was performed to identify independent prognostic factors associated with cancer-specific survival. Results: The median age of the patients was 72 (30–95) years. There was no significant difference in terms of tumor characteristics, concomitant adenocarcinoma grade, SEER stage, and treatment (including prostatectomy and radiation therapy) received between the groups. Median cancer-specific survival was 19 months (95% confidence interval 13–25). By multivariate Cox proportional hazard modeling, older age group (hazard ratio [HR] 1.95; P = 0.001), concomitant high-grade adenocarcinoma (HR 7.13; P = 0.007), and not having prostatectomy (HR 3.77; P = 0.005) were found to be significant independent predictors of poor cancer-specific survival. Conclusion: Older patients with SCCP had increased risk of poor cancer-specific survival. Whether this age-related poor outcome can be attributed to more aggressive tumor biology in older patients, or is simply a reflection of age-related poor performance status and suboptimal chemotherapy needs further investigation. Keywords: small-cell carcinoma, prostate, radical prostatectomy, radiation, cancer-specific survival, age
format	article
author	Wang J Wang FW
author_facet	Wang J Wang FW
author_sort	Wang J
title	Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate
title_short	Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate
title_full	Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate
title_fullStr	Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate
title_full_unstemmed	Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate
title_sort	impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/cdfb7b9483314fc4beb7cf399011f9af
work_keys_str_mv	AT wangj impactofageonclinicalpresentationtreatmentandcancerspecificsurvivalofpatientswithsmallcellcarcinomaoftheprostate AT wangfw impactofageonclinicalpresentationtreatmentandcancerspecificsurvivalofpatientswithsmallcellcarcinomaoftheprostate
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Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate

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