Neural signatures of hyperdirect pathway activity in Parkinson’s disease

Neural signatures of hyperdirect pathway activity in Parkinson’s disease

In Parkinson’s disease (PD), beta frequency oscillations are synchronised across the cortico-basal-ganglia circuit. The authors show in human participants that high beta frequencies propagate from the cortex to the basal ganglia via the hyperdirect pathway, indicating a pathophysiological role for t...

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Autores principales: Ashwini Oswal, Chunyan Cao, Chien-Hung Yeh, Wolf-Julian Neumann, James Gratwicke, Harith Akram, Andreas Horn, Dianyou Li, Shikun Zhan, Chao Zhang, Qiang Wang, Ludvic Zrinzo, Tom Foltynie, Patricia Limousin, Rafal Bogacz, Bomin Sun, Masud Husain, Peter Brown, Vladimir Litvak
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/cdfc65b27df649a2be40ee8e183add84
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Sumario:In Parkinson’s disease (PD), beta frequency oscillations are synchronised across the cortico-basal-ganglia circuit. The authors show in human participants that high beta frequencies propagate from the cortex to the basal ganglia via the hyperdirect pathway, indicating a pathophysiological role for this pathway in PD.

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