Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up

We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contr...

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Autores principales:	Izabella Karska-Basta, Bożena Romanowska-Dixon, Dorota Pojda-Wilczek, Alina Bakunowicz-Łazarczyk, Agnieszka Kubicka-Trząska, Karolina Gerba-Górecka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	AZOOR epilepsy electrophysiology Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cdffc6f5614d4819bc7cde5298f0f87c
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spelling	oai:doaj.org-article:cdffc6f5614d4819bc7cde5298f0f87c2021-11-25T18:19:10ZAcute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up10.3390/medicina571112761648-91441010-660Xhttps://doaj.org/article/cdffc6f5614d4819bc7cde5298f0f87c2021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1276https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contribute to an inflammatory response both in the brain and the retina. A 13-year-old male patient with epilepsy was referred by a neurologist for an ophthalmologic consultation due to a sudden deterioration of visual acuity in the left eye. The examination, with a key role of multimodal imaging including color fundus photography, fluorescein angiography, indocyanine green angiography (ICGA), fundus autofluorescence (FAF), swept-source optical coherence tomography (SS-OCT) with visual field assessment, and electroretinography indicated AZOOR as the underlying entity. Findings at the first admission included enlargement of the blind spot in visual field examination along a typical trizonal pattern, which was revealed by FAF, ICGA, and SS-OCT in the left eye. The right eye exhibited no abnormalities. Seminal follow-up revealed no changes in best corrected visual acuity, and multimodal imaging findings remain unaltered. Thus, no medical intervention is required. Our case and recent laboratory findings suggest a causative link between epilepsy and retinal disorders, although this issue requires further research.Izabella Karska-BastaBożena Romanowska-DixonDorota Pojda-WilczekAlina Bakunowicz-ŁazarczykAgnieszka Kubicka-TrząskaKarolina Gerba-GóreckaMDPI AGarticleAZOORepilepsyelectrophysiologyMedicine (General)R5-920ENMedicina, Vol 57, Iss 1276, p 1276 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AZOOR epilepsy electrophysiology Medicine (General) R5-920
spellingShingle	AZOOR epilepsy electrophysiology Medicine (General) R5-920 Izabella Karska-Basta Bożena Romanowska-Dixon Dorota Pojda-Wilczek Alina Bakunowicz-Łazarczyk Agnieszka Kubicka-Trząska Karolina Gerba-Górecka Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
description	We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contribute to an inflammatory response both in the brain and the retina. A 13-year-old male patient with epilepsy was referred by a neurologist for an ophthalmologic consultation due to a sudden deterioration of visual acuity in the left eye. The examination, with a key role of multimodal imaging including color fundus photography, fluorescein angiography, indocyanine green angiography (ICGA), fundus autofluorescence (FAF), swept-source optical coherence tomography (SS-OCT) with visual field assessment, and electroretinography indicated AZOOR as the underlying entity. Findings at the first admission included enlargement of the blind spot in visual field examination along a typical trizonal pattern, which was revealed by FAF, ICGA, and SS-OCT in the left eye. The right eye exhibited no abnormalities. Seminal follow-up revealed no changes in best corrected visual acuity, and multimodal imaging findings remain unaltered. Thus, no medical intervention is required. Our case and recent laboratory findings suggest a causative link between epilepsy and retinal disorders, although this issue requires further research.
format	article
author	Izabella Karska-Basta Bożena Romanowska-Dixon Dorota Pojda-Wilczek Alina Bakunowicz-Łazarczyk Agnieszka Kubicka-Trząska Karolina Gerba-Górecka
author_facet	Izabella Karska-Basta Bożena Romanowska-Dixon Dorota Pojda-Wilczek Alina Bakunowicz-Łazarczyk Agnieszka Kubicka-Trząska Karolina Gerba-Górecka
author_sort	Izabella Karska-Basta
title	Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_short	Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_full	Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_fullStr	Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_full_unstemmed	Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_sort	acute zonal occult outer retinopathy in a patient suffering from epilepsy: five-year follow-up
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cdffc6f5614d4819bc7cde5298f0f87c
work_keys_str_mv	AT izabellakarskabasta acutezonaloccultouterretinopathyinapatientsufferingfromepilepsyfiveyearfollowup AT bozenaromanowskadixon acutezonaloccultouterretinopathyinapatientsufferingfromepilepsyfiveyearfollowup AT dorotapojdawilczek acutezonaloccultouterretinopathyinapatientsufferingfromepilepsyfiveyearfollowup AT alinabakunowiczłazarczyk acutezonaloccultouterretinopathyinapatientsufferingfromepilepsyfiveyearfollowup AT agnieszkakubickatrzaska acutezonaloccultouterretinopathyinapatientsufferingfromepilepsyfiveyearfollowup AT karolinagerbagorecka acutezonaloccultouterretinopathyinapatientsufferingfromepilepsyfiveyearfollowup
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Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up

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