Application of dental nanomaterials: potential toxicity to the central nervous system

Xiaoli Feng,1 Aijie Chen,1 Yanli Zhang,1 Jianfeng Wang,2 Longquan Shao,1 Limin Wei2 1Nanfang Hospital, Southern Medical University, Guangzhou, 2School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Nanomaterials are defined as mater...

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Autores principales:	Feng X, Chen A, Zhang Y, Wang J, Shao L, Wei L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ce005d1573194c269796c9bf4a93b6de
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spelling	oai:doaj.org-article:ce005d1573194c269796c9bf4a93b6de2021-12-02T03:10:57ZApplication of dental nanomaterials: potential toxicity to the central nervous system1178-2013https://doaj.org/article/ce005d1573194c269796c9bf4a93b6de2015-05-01T00:00:00Zhttp://www.dovepress.com/application-of-dental-nanomaterials-potential-toxicity-to-the-central--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaoli Feng,1 Aijie Chen,1 Yanli Zhang,1 Jianfeng Wang,2 Longquan Shao,1 Limin Wei2 1Nanfang Hospital, Southern Medical University, Guangzhou, 2School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Nanomaterials are defined as materials with one or more external dimensions with a size of 1–100 nm. Such materials possess typical nanostructure-dependent properties (eg, chemical, biological, optical, mechanical, and magnetic), which may differ greatly from the properties of their bulk counterparts. In recent years, nanomaterials have been widely used in the production of dental materials, particularly in light polymerization composite resins and bonding systems, coating materials for dental implants, bioceramics, endodontic sealers, and mouthwashes. However, the dental applications of nanomaterials yield not only a significant improvement in clinical treatments but also growing concerns regarding their biosecurity. The brain is well protected by the blood–brain barrier (BBB), which separates the blood from the cerebral parenchyma. However, in recent years, many studies have found that nanoparticles (NPs), including nanocarriers, can transport through the BBB and locate in the central nervous system (CNS). Because the CNS may be a potential target organ of the nanomaterials, it is essential to determine the neurotoxic effects of NPs. In this review, possible dental nanomaterials and their pathways into the CNS are discussed, as well as related neurotoxicity effects underlying the in vitro and in vivo studies. Finally, we analyze the limitations of the current testing methods on the toxicological effects of nanomaterials. This review contributes to a better understanding of the nano-related risks to the CNS as well as the further development of safety assessment systems. Keywords: dental, nanomaterials, central nervous system, toxicity, testing methods, risk assessmentFeng XChen AZhang YWang JShao LWei LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3547-3565 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Feng X Chen A Zhang Y Wang J Shao L Wei L Application of dental nanomaterials: potential toxicity to the central nervous system
description	Xiaoli Feng,1 Aijie Chen,1 Yanli Zhang,1 Jianfeng Wang,2 Longquan Shao,1 Limin Wei2 1Nanfang Hospital, Southern Medical University, Guangzhou, 2School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Nanomaterials are defined as materials with one or more external dimensions with a size of 1–100 nm. Such materials possess typical nanostructure-dependent properties (eg, chemical, biological, optical, mechanical, and magnetic), which may differ greatly from the properties of their bulk counterparts. In recent years, nanomaterials have been widely used in the production of dental materials, particularly in light polymerization composite resins and bonding systems, coating materials for dental implants, bioceramics, endodontic sealers, and mouthwashes. However, the dental applications of nanomaterials yield not only a significant improvement in clinical treatments but also growing concerns regarding their biosecurity. The brain is well protected by the blood–brain barrier (BBB), which separates the blood from the cerebral parenchyma. However, in recent years, many studies have found that nanoparticles (NPs), including nanocarriers, can transport through the BBB and locate in the central nervous system (CNS). Because the CNS may be a potential target organ of the nanomaterials, it is essential to determine the neurotoxic effects of NPs. In this review, possible dental nanomaterials and their pathways into the CNS are discussed, as well as related neurotoxicity effects underlying the in vitro and in vivo studies. Finally, we analyze the limitations of the current testing methods on the toxicological effects of nanomaterials. This review contributes to a better understanding of the nano-related risks to the CNS as well as the further development of safety assessment systems. Keywords: dental, nanomaterials, central nervous system, toxicity, testing methods, risk assessment
format	article
author	Feng X Chen A Zhang Y Wang J Shao L Wei L
author_facet	Feng X Chen A Zhang Y Wang J Shao L Wei L
author_sort	Feng X
title	Application of dental nanomaterials: potential toxicity to the central nervous system
title_short	Application of dental nanomaterials: potential toxicity to the central nervous system
title_full	Application of dental nanomaterials: potential toxicity to the central nervous system
title_fullStr	Application of dental nanomaterials: potential toxicity to the central nervous system
title_full_unstemmed	Application of dental nanomaterials: potential toxicity to the central nervous system
title_sort	application of dental nanomaterials: potential toxicity to the central nervous system
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/ce005d1573194c269796c9bf4a93b6de
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Application of dental nanomaterials: potential toxicity to the central nervous system

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