Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

The transient receptor potential channel TRPV6 mediates calcium uptake in epithelia and its expression is increased in several cancer types. Here, authors present structures of TRPV6 bound to 2-APB, a TRPV6 inhibitor, and show that 2-APB induces TRPV6 channel closure by modulating protein–lipid inte...

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Autores principales:	Appu K. Singh, Kei Saotome, Luke L. McGoldrick, Alexander I. Sobolevsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce026764db1c4dd392a42c150edffb58
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spelling	oai:doaj.org-article:ce026764db1c4dd392a42c150edffb582021-12-02T14:39:25ZStructural bases of TRP channel TRPV6 allosteric modulation by 2-APB10.1038/s41467-018-04828-y2041-1723https://doaj.org/article/ce026764db1c4dd392a42c150edffb582018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04828-yhttps://doaj.org/toc/2041-1723The transient receptor potential channel TRPV6 mediates calcium uptake in epithelia and its expression is increased in several cancer types. Here, authors present structures of TRPV6 bound to 2-APB, a TRPV6 inhibitor, and show that 2-APB induces TRPV6 channel closure by modulating protein–lipid interactions.Appu K. SinghKei SaotomeLuke L. McGoldrickAlexander I. SobolevskyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Appu K. Singh Kei Saotome Luke L. McGoldrick Alexander I. Sobolevsky Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB
description	The transient receptor potential channel TRPV6 mediates calcium uptake in epithelia and its expression is increased in several cancer types. Here, authors present structures of TRPV6 bound to 2-APB, a TRPV6 inhibitor, and show that 2-APB induces TRPV6 channel closure by modulating protein–lipid interactions.
format	article
author	Appu K. Singh Kei Saotome Luke L. McGoldrick Alexander I. Sobolevsky
author_facet	Appu K. Singh Kei Saotome Luke L. McGoldrick Alexander I. Sobolevsky
author_sort	Appu K. Singh
title	Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB
title_short	Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB
title_full	Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB
title_fullStr	Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB
title_full_unstemmed	Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB
title_sort	structural bases of trp channel trpv6 allosteric modulation by 2-apb
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ce026764db1c4dd392a42c150edffb58
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Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

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