Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses

Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune responses, reducing tumor growth in preclinical can...

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Autores principales:	Burhan Uyanik, Anastasia R. Goloudina, Aamir Akbarali, Bogdan B. Grigorash, Alexey V. Petukhov, Sunil Singhal, Evgeniy Eruslanov, Jeanne Chaloyard, Lisa Lagorgette, Tarik Hadi, Ekaterina V. Baidyuk, Hiroyasu Sakai, Lino Tessarollo, Bernhard Ryffel, Sharlyn J. Mazur, Frederic Lirussi, Carmen Garrido, Ettore Appella, Oleg N. Demidov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce056f276c7b4010b02dce368383e9c8
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spelling	oai:doaj.org-article:ce056f276c7b4010b02dce368383e9c82021-12-02T17:39:48ZInhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses10.1038/s41467-021-23330-62041-1723https://doaj.org/article/ce056f276c7b4010b02dce368383e9c82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23330-6https://doaj.org/toc/2041-1723Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune responses, reducing tumor growth in preclinical cancer models.Burhan UyanikAnastasia R. GoloudinaAamir AkbaraliBogdan B. GrigorashAlexey V. PetukhovSunil SinghalEvgeniy EruslanovJeanne ChaloyardLisa LagorgetteTarik HadiEkaterina V. BaidyukHiroyasu SakaiLino TessarolloBernhard RyffelSharlyn J. MazurFrederic LirussiCarmen GarridoEttore AppellaOleg N. DemidovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Burhan Uyanik Anastasia R. Goloudina Aamir Akbarali Bogdan B. Grigorash Alexey V. Petukhov Sunil Singhal Evgeniy Eruslanov Jeanne Chaloyard Lisa Lagorgette Tarik Hadi Ekaterina V. Baidyuk Hiroyasu Sakai Lino Tessarollo Bernhard Ryffel Sharlyn J. Mazur Frederic Lirussi Carmen Garrido Ettore Appella Oleg N. Demidov Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
description	Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune responses, reducing tumor growth in preclinical cancer models.
format	article
author	Burhan Uyanik Anastasia R. Goloudina Aamir Akbarali Bogdan B. Grigorash Alexey V. Petukhov Sunil Singhal Evgeniy Eruslanov Jeanne Chaloyard Lisa Lagorgette Tarik Hadi Ekaterina V. Baidyuk Hiroyasu Sakai Lino Tessarollo Bernhard Ryffel Sharlyn J. Mazur Frederic Lirussi Carmen Garrido Ettore Appella Oleg N. Demidov
author_facet	Burhan Uyanik Anastasia R. Goloudina Aamir Akbarali Bogdan B. Grigorash Alexey V. Petukhov Sunil Singhal Evgeniy Eruslanov Jeanne Chaloyard Lisa Lagorgette Tarik Hadi Ekaterina V. Baidyuk Hiroyasu Sakai Lino Tessarollo Bernhard Ryffel Sharlyn J. Mazur Frederic Lirussi Carmen Garrido Ettore Appella Oleg N. Demidov
author_sort	Burhan Uyanik
title	Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
title_short	Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
title_full	Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
title_fullStr	Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
title_full_unstemmed	Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
title_sort	inhibition of the dna damage response phosphatase ppm1d reprograms neutrophils to enhance anti-tumor immune responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ce056f276c7b4010b02dce368383e9c8
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Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses

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