Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.

Dengue fever is the most important arboviral disease world-wide, with Aedes aegypti being the major vector. Interactions between the mosquito host and dengue viruses (DENV) are complex and vector competence varies among geographically-distinct Ae. aegypti populations. Additionally, dengue is caused...

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Autores principales:	Mariangela Bonizzoni, W Augustine Dunn, Corey L Campbell, Ken E Olson, Osvaldo Marinotti, Anthony A James
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce088ce5705d47c2abeceeb0753ef5b1
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spelling	oai:doaj.org-article:ce088ce5705d47c2abeceeb0753ef5b12021-11-18T08:07:22ZComplex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.1932-620310.1371/journal.pone.0050512https://doaj.org/article/ce088ce5705d47c2abeceeb0753ef5b12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209765/?tool=EBIhttps://doaj.org/toc/1932-6203Dengue fever is the most important arboviral disease world-wide, with Aedes aegypti being the major vector. Interactions between the mosquito host and dengue viruses (DENV) are complex and vector competence varies among geographically-distinct Ae. aegypti populations. Additionally, dengue is caused by four antigenically-distinct viral serotypes (DENV1-4), each with multiple genotypes. Each virus genotype interacts differently with vertebrate and invertebrate hosts. Analyses of alterations in mosquito transcriptional profiles during DENV infection are expected to provide the basis for identifying networks of genes involved in responses to viruses and contribute to the molecular-genetic understanding of vector competence. In addition, this knowledge is anticipated to support the development of novel disease-control strategies. RNA-seq technology was used to assess genome-wide changes in transcript abundance at 1, 4 and 14 days following DENV2 infection in carcasses, midguts and salivary glands of the Ae. aegypti Chetumal strain. DENV2 affected the expression of 397 Ae. aegypti genes, most of which were down-regulated by viral infection. Differential accumulation of transcripts was mainly tissue- and time-specific. Comparisons of our data with other published reports reveal conservation of functional classes, but limited concordance of specific mosquito genes responsive to DENV2 infection. These results indicate the necessity of additional studies of mosquito-DENV interactions, specifically those focused on recently-derived mosquito strains with multiple dengue virus serotypes and genotypes.Mariangela BonizzoniW Augustine DunnCorey L CampbellKen E OlsonOsvaldo MarinottiAnthony A JamesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50512 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mariangela Bonizzoni W Augustine Dunn Corey L Campbell Ken E Olson Osvaldo Marinotti Anthony A James Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.
description	Dengue fever is the most important arboviral disease world-wide, with Aedes aegypti being the major vector. Interactions between the mosquito host and dengue viruses (DENV) are complex and vector competence varies among geographically-distinct Ae. aegypti populations. Additionally, dengue is caused by four antigenically-distinct viral serotypes (DENV1-4), each with multiple genotypes. Each virus genotype interacts differently with vertebrate and invertebrate hosts. Analyses of alterations in mosquito transcriptional profiles during DENV infection are expected to provide the basis for identifying networks of genes involved in responses to viruses and contribute to the molecular-genetic understanding of vector competence. In addition, this knowledge is anticipated to support the development of novel disease-control strategies. RNA-seq technology was used to assess genome-wide changes in transcript abundance at 1, 4 and 14 days following DENV2 infection in carcasses, midguts and salivary glands of the Ae. aegypti Chetumal strain. DENV2 affected the expression of 397 Ae. aegypti genes, most of which were down-regulated by viral infection. Differential accumulation of transcripts was mainly tissue- and time-specific. Comparisons of our data with other published reports reveal conservation of functional classes, but limited concordance of specific mosquito genes responsive to DENV2 infection. These results indicate the necessity of additional studies of mosquito-DENV interactions, specifically those focused on recently-derived mosquito strains with multiple dengue virus serotypes and genotypes.
format	article
author	Mariangela Bonizzoni W Augustine Dunn Corey L Campbell Ken E Olson Osvaldo Marinotti Anthony A James
author_facet	Mariangela Bonizzoni W Augustine Dunn Corey L Campbell Ken E Olson Osvaldo Marinotti Anthony A James
author_sort	Mariangela Bonizzoni
title	Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.
title_short	Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.
title_full	Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.
title_fullStr	Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.
title_full_unstemmed	Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.
title_sort	complex modulation of the aedes aegypti transcriptome in response to dengue virus infection.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ce088ce5705d47c2abeceeb0753ef5b1
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Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection.

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