Antimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin

Objectives: Escherichia coli (E. coli)-induced urinary tract infection (UTI) is a common infection associated with frequent use of antibiotics and the increase in global antibiotic resistances. We aimed to determine the susceptibility profile of extended-spectrum β-lactamase (ESBL) producing E. coli...

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Autores principales:	Nermin Kamal Saeed, Safaa Al Khawaja, Mohammed Al-Biltagi
Formato:	article
Lenguaje:	EN
Publicado:	Oman Medical Specialty Board 2021
Materias:	urinary tract infections escherichia coli fosfomycin bahrain Medicine R
Acceso en línea:	https://doaj.org/article/ce0fee85bebc4cad88d4119243a3755e
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spelling	oai:doaj.org-article:ce0fee85bebc4cad88d4119243a3755e2021-11-10T11:02:27ZAntimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin10.5001/omj.2021.951999-768X2070-5204https://doaj.org/article/ce0fee85bebc4cad88d4119243a3755e2021-11-01T00:00:00Zhttps://omjournal.org/articleDetails.aspx?coType=1&aId=3013https://doaj.org/toc/1999-768Xhttps://doaj.org/toc/2070-5204Objectives: Escherichia coli (E. coli)-induced urinary tract infection (UTI) is a common infection associated with frequent use of antibiotics and the increase in global antibiotic resistances. We aimed to determine the susceptibility profile of extended-spectrum β-lactamase (ESBL) producing E. coli isolated from the urinary samples to fosfomycin and other antibiotics. Methods: We retrospectively analyzed urine samples with ESBL-producing E. coli isolates obtained between January 2018 and December 2019 in the Microbiology Section, Salmaniya Medical Complex, Bahrain. We collected and analyzed all the E. coli urinary isolates’ data and their antibiotic susceptibility patterns. Results: The study included 3044 E. coli isolates with 50.6% obtained in 2018 and 49.4% in 2019; 38.1% (1161 isolates) were ESBL E. coli, and 0.7% (21 isolates) were carbapenem-resistant Enterobacteriaceae (CRE). There were 1161 (38.1%) isolates with ESBL-producing E. coli, with 37.3% isolated in 2018 and 39.0% isolated in 2019. The antibiotic susceptibility of ESBL-producing E. coli during the study period showed susceptibility to trimethoprim/sulfamethoxazole in 46.1% of isolates (50.2% in 2018 dropped to 41.9% in 2019), to ciprofloxacin in 49.0% of isolates (49.5% in 2018 dropped to 48.4% in 2019), to nitrofurantoin in 91.8% of isolates (94.3 in 2018 dropped to 89.3% in 2019), and to fosfomycin in 97.6% of isolates (98.8% in 2018 dropped to 96.3% in 2019). Conclusions: ESBL-producing E. coli is an important cause of UTI in Bahrain. Fosfomycin is a very effective oral antimicrobial that retains high efficacy against ESBL-producing E. coli, which helps decrease the need for parenteral therapy and, consequently, hospitalization.Nermin Kamal SaeedSafaa Al KhawajaMohammed Al-BiltagiOman Medical Specialty Boardarticleurinary tract infectionsescherichia colifosfomycinbahrainMedicineRENOman Medical Journal, Vol 36, Iss 6, Pp e314-e314 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	urinary tract infections escherichia coli fosfomycin bahrain Medicine R
spellingShingle	urinary tract infections escherichia coli fosfomycin bahrain Medicine R Nermin Kamal Saeed Safaa Al Khawaja Mohammed Al-Biltagi Antimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin
description	Objectives: Escherichia coli (E. coli)-induced urinary tract infection (UTI) is a common infection associated with frequent use of antibiotics and the increase in global antibiotic resistances. We aimed to determine the susceptibility profile of extended-spectrum β-lactamase (ESBL) producing E. coli isolated from the urinary samples to fosfomycin and other antibiotics. Methods: We retrospectively analyzed urine samples with ESBL-producing E. coli isolates obtained between January 2018 and December 2019 in the Microbiology Section, Salmaniya Medical Complex, Bahrain. We collected and analyzed all the E. coli urinary isolates’ data and their antibiotic susceptibility patterns. Results: The study included 3044 E. coli isolates with 50.6% obtained in 2018 and 49.4% in 2019; 38.1% (1161 isolates) were ESBL E. coli, and 0.7% (21 isolates) were carbapenem-resistant Enterobacteriaceae (CRE). There were 1161 (38.1%) isolates with ESBL-producing E. coli, with 37.3% isolated in 2018 and 39.0% isolated in 2019. The antibiotic susceptibility of ESBL-producing E. coli during the study period showed susceptibility to trimethoprim/sulfamethoxazole in 46.1% of isolates (50.2% in 2018 dropped to 41.9% in 2019), to ciprofloxacin in 49.0% of isolates (49.5% in 2018 dropped to 48.4% in 2019), to nitrofurantoin in 91.8% of isolates (94.3 in 2018 dropped to 89.3% in 2019), and to fosfomycin in 97.6% of isolates (98.8% in 2018 dropped to 96.3% in 2019). Conclusions: ESBL-producing E. coli is an important cause of UTI in Bahrain. Fosfomycin is a very effective oral antimicrobial that retains high efficacy against ESBL-producing E. coli, which helps decrease the need for parenteral therapy and, consequently, hospitalization.
format	article
author	Nermin Kamal Saeed Safaa Al Khawaja Mohammed Al-Biltagi
author_facet	Nermin Kamal Saeed Safaa Al Khawaja Mohammed Al-Biltagi
author_sort	Nermin Kamal Saeed
title	Antimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin
title_short	Antimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin
title_full	Antimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin
title_fullStr	Antimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin
title_full_unstemmed	Antimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin
title_sort	antimicrobial susceptibilities of urinary extended-spectrum β-lactamase escherichia coli to fosfomycin
publisher	Oman Medical Specialty Board
publishDate	2021
url	https://doaj.org/article/ce0fee85bebc4cad88d4119243a3755e
work_keys_str_mv	AT nerminkamalsaeed antimicrobialsusceptibilitiesofurinaryextendedspectrumblactamaseescherichiacolitofosfomycin AT safaaalkhawaja antimicrobialsusceptibilitiesofurinaryextendedspectrumblactamaseescherichiacolitofosfomycin AT mohammedalbiltagi antimicrobialsusceptibilitiesofurinaryextendedspectrumblactamaseescherichiacolitofosfomycin
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Antimicrobial Susceptibilities of Urinary Extended-spectrum β-lactamase Escherichia coli to Fosfomycin

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