Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection

Abstract Extracellular vesicles (EVs) can participate in intercellular communication and pathogenesis. EVs contain many cargos, including proteins, and the composition of EVs differs between cell-types and activation levels. Thus, plasma EVs can be used as a biomarker of systemic response to infecti...

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Autores principales:	Patricia Jeannin, Thibault Chaze, Quentin Giai Gianetto, Mariette Matondo, Olivier Gout, Antoine Gessain, Philippe V. Afonso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce1105a8d4d94c4883b20505984f41f0
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spelling	oai:doaj.org-article:ce1105a8d4d94c4883b20505984f41f02021-12-02T15:07:46ZProteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection10.1038/s41598-018-23505-02045-2322https://doaj.org/article/ce1105a8d4d94c4883b20505984f41f02018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23505-0https://doaj.org/toc/2045-2322Abstract Extracellular vesicles (EVs) can participate in intercellular communication and pathogenesis. EVs contain many cargos, including proteins, and the composition of EVs differs between cell-types and activation levels. Thus, plasma EVs can be used as a biomarker of systemic response to infection and/or disease progression. In this study, we aimed at describing alterations in the protein content of plasma EVs upon infection with the human T-lymphotropic retrovirus type 1 (HTLV-1). HTLV-1 is the etiological agent of a lymphoproliferative disease (ATL) and a series of inflammatory diseases, including a neurodegenerative inflammatory disease (HAM/TSP). We found that plasma EVs are more abundant and smaller in HTLV-1 asymptomatic carriers or HAM/TSP patients when compared to uninfected healthy donors. Moreover, EVs from HTLV-1 infected donors contain markers of metabolic and mitochondrial stress.Patricia JeanninThibault ChazeQuentin Giai GianettoMariette MatondoOlivier GoutAntoine GessainPhilippe V. AfonsoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patricia Jeannin Thibault Chaze Quentin Giai Gianetto Mariette Matondo Olivier Gout Antoine Gessain Philippe V. Afonso Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection
description	Abstract Extracellular vesicles (EVs) can participate in intercellular communication and pathogenesis. EVs contain many cargos, including proteins, and the composition of EVs differs between cell-types and activation levels. Thus, plasma EVs can be used as a biomarker of systemic response to infection and/or disease progression. In this study, we aimed at describing alterations in the protein content of plasma EVs upon infection with the human T-lymphotropic retrovirus type 1 (HTLV-1). HTLV-1 is the etiological agent of a lymphoproliferative disease (ATL) and a series of inflammatory diseases, including a neurodegenerative inflammatory disease (HAM/TSP). We found that plasma EVs are more abundant and smaller in HTLV-1 asymptomatic carriers or HAM/TSP patients when compared to uninfected healthy donors. Moreover, EVs from HTLV-1 infected donors contain markers of metabolic and mitochondrial stress.
format	article
author	Patricia Jeannin Thibault Chaze Quentin Giai Gianetto Mariette Matondo Olivier Gout Antoine Gessain Philippe V. Afonso
author_facet	Patricia Jeannin Thibault Chaze Quentin Giai Gianetto Mariette Matondo Olivier Gout Antoine Gessain Philippe V. Afonso
author_sort	Patricia Jeannin
title	Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection
title_short	Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection
title_full	Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection
title_fullStr	Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection
title_full_unstemmed	Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection
title_sort	proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon htlv-1 infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ce1105a8d4d94c4883b20505984f41f0
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Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection

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