Structural Analysis on the Severe Acute Respiratory Syndrome Coronavirus 2 Non-structural Protein 13 Mutants Revealed Altered Bonding Network With TANK Binding Kinase 1 to Evade Host Immune System

Structural Analysis on the Severe Acute Respiratory Syndrome Coronavirus 2 Non-structural Protein 13 Mutants Revealed Altered Bonding Network With TANK Binding Kinase 1 to Evade Host Immune System

Mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have made this virus more infectious. Previous studies have confirmed that non-structural protein 13 (NSP13) plays an important role in immune evasion by physically interacting with TANK binding kinase 1 (TBK1) to inhibit IFNβ...

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Autores principales: Farooq Rashid, Muhammad Suleman, Abdullah Shah, Emmanuel Enoch Dzakah, Shuyi Chen, Haiying Wang, Shixing Tang
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
SARS-CoV-2
NSP13 mutants
TBK1
protein-protein docking
MD simulations
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/ce14dc80dd234254b629648c94dbb665
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