Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort.
<h4>Objective</h4>This study aimed to investigate whether or not hypoxia-inducible factor-1α (HIF-1α) gene variants are associated with the susceptibility and clinical characteristics of lumbar disc degeneration (LDD).<h4>Methods</h4>We examined 320 patients with LDD and 447...
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oai:doaj.org-article:ce159134f2df4b80b7771da38e6f737c2021-11-18T08:58:10ZPolymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort.1932-620310.1371/journal.pone.0073158https://doaj.org/article/ce159134f2df4b80b7771da38e6f737c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23991178/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>This study aimed to investigate whether or not hypoxia-inducible factor-1α (HIF-1α) gene variants are associated with the susceptibility and clinical characteristics of lumbar disc degeneration (LDD).<h4>Methods</h4>We examined 320 patients with LDD and 447 gender- and age-matched control subjects. We also determined the HIF-1α gene variants, including C1772T (P582S) and G1790A (A588T) polymorphisms.<h4>Results</h4>Significant differences were observed in allelic and genotypic distributions of 1790 A > G polymorphisms between LDD cases and control subjects. Logistic regression revealed that 1790 AA genotypes indicated a protective effect against the development of LDD. The HIF-1α 1790 A > G polymorphisms also affected the severity of LDD as evaluated based on the modified Japanese Orthopedic Association (mJOA) scores. The 1790 AA genotype carriers exhibited significantly lower mJOA scores than AG and GG carriers. C1772T did not show any association with the risk and severity of LDD.<h4>Conclusion</h4>Our study suggested that HIF-1α 1790 A > G polymorphisms may be used as a molecular marker to determine the susceptibility and severity of LDD.Wen-Ping LinXue-Jin WangCong-Ren WangLi-Qun ZhangNeng LiFa-Sheng WangJian-Hua LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e73158 (2013) |
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Medicine R Science Q Wen-Ping Lin Xue-Jin Wang Cong-Ren Wang Li-Qun Zhang Neng Li Fa-Sheng Wang Jian-Hua Lin Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort. |
| description |
<h4>Objective</h4>This study aimed to investigate whether or not hypoxia-inducible factor-1α (HIF-1α) gene variants are associated with the susceptibility and clinical characteristics of lumbar disc degeneration (LDD).<h4>Methods</h4>We examined 320 patients with LDD and 447 gender- and age-matched control subjects. We also determined the HIF-1α gene variants, including C1772T (P582S) and G1790A (A588T) polymorphisms.<h4>Results</h4>Significant differences were observed in allelic and genotypic distributions of 1790 A > G polymorphisms between LDD cases and control subjects. Logistic regression revealed that 1790 AA genotypes indicated a protective effect against the development of LDD. The HIF-1α 1790 A > G polymorphisms also affected the severity of LDD as evaluated based on the modified Japanese Orthopedic Association (mJOA) scores. The 1790 AA genotype carriers exhibited significantly lower mJOA scores than AG and GG carriers. C1772T did not show any association with the risk and severity of LDD.<h4>Conclusion</h4>Our study suggested that HIF-1α 1790 A > G polymorphisms may be used as a molecular marker to determine the susceptibility and severity of LDD. |
| format |
article |
| author |
Wen-Ping Lin Xue-Jin Wang Cong-Ren Wang Li-Qun Zhang Neng Li Fa-Sheng Wang Jian-Hua Lin |
| author_facet |
Wen-Ping Lin Xue-Jin Wang Cong-Ren Wang Li-Qun Zhang Neng Li Fa-Sheng Wang Jian-Hua Lin |
| author_sort |
Wen-Ping Lin |
| title |
Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort. |
| title_short |
Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort. |
| title_full |
Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort. |
| title_fullStr |
Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort. |
| title_full_unstemmed |
Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort. |
| title_sort |
polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to ldd in chinese cohort. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/ce159134f2df4b80b7771da38e6f737c |
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| _version_ |
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