mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity

Abstract We performed a systematic identification of microRNAs (miRNAs) involved in the control of innate immunity. We identified 7 novel miRNA mutants with altered survival, colony forming in the body, and expression pattern of putative antimicrobial genes after Pseudomonas aeruginosa infection. Lo...

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Autores principales:	Lingtong Zhi, Yonglin Yu, Zhixia Jiang, Dayong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce189835da2248e8999a4e77a0ee415c
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spelling	oai:doaj.org-article:ce189835da2248e8999a4e77a0ee415c2021-12-02T15:06:06Zmir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity10.1038/s41598-017-15271-22045-2322https://doaj.org/article/ce189835da2248e8999a4e77a0ee415c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-15271-2https://doaj.org/toc/2045-2322Abstract We performed a systematic identification of microRNAs (miRNAs) involved in the control of innate immunity. We identified 7 novel miRNA mutants with altered survival, colony forming in the body, and expression pattern of putative antimicrobial genes after Pseudomonas aeruginosa infection. Loss-of-function mutation of mir-45, mir-75, mir-246, mir-256, or mir-355 induced resistance to P. aeruginosa infection, whereas loss-of-function mutation of mir-63 or mir-360 induced susceptibility to P. aeruginosa infection. DAF-2 in the insulin signaling pathway acted as a target for intestinal mir-355 to regulate innate immunity. mir-355 functioned as an important link between p38 MAPK signaling pathway and insulin signaling pathway in the regulation of innate immunity. Our results provide an important molecular basis for further elucidation of the functions of various miRNAs in the regulation of innate immunity.Lingtong ZhiYonglin YuZhixia JiangDayong WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingtong Zhi Yonglin Yu Zhixia Jiang Dayong Wang mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity
description	Abstract We performed a systematic identification of microRNAs (miRNAs) involved in the control of innate immunity. We identified 7 novel miRNA mutants with altered survival, colony forming in the body, and expression pattern of putative antimicrobial genes after Pseudomonas aeruginosa infection. Loss-of-function mutation of mir-45, mir-75, mir-246, mir-256, or mir-355 induced resistance to P. aeruginosa infection, whereas loss-of-function mutation of mir-63 or mir-360 induced susceptibility to P. aeruginosa infection. DAF-2 in the insulin signaling pathway acted as a target for intestinal mir-355 to regulate innate immunity. mir-355 functioned as an important link between p38 MAPK signaling pathway and insulin signaling pathway in the regulation of innate immunity. Our results provide an important molecular basis for further elucidation of the functions of various miRNAs in the regulation of innate immunity.
format	article
author	Lingtong Zhi Yonglin Yu Zhixia Jiang Dayong Wang
author_facet	Lingtong Zhi Yonglin Yu Zhixia Jiang Dayong Wang
author_sort	Lingtong Zhi
title	mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity
title_short	mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity
title_full	mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity
title_fullStr	mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity
title_full_unstemmed	mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity
title_sort	mir-355 functions as an important link between p38 mapk signaling and insulin signaling in the regulation of innate immunity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ce189835da2248e8999a4e77a0ee415c
work_keys_str_mv	AT lingtongzhi mir355functionsasanimportantlinkbetweenp38mapksignalingandinsulinsignalingintheregulationofinnateimmunity AT yonglinyu mir355functionsasanimportantlinkbetweenp38mapksignalingandinsulinsignalingintheregulationofinnateimmunity AT zhixiajiang mir355functionsasanimportantlinkbetweenp38mapksignalingandinsulinsignalingintheregulationofinnateimmunity AT dayongwang mir355functionsasanimportantlinkbetweenp38mapksignalingandinsulinsignalingintheregulationofinnateimmunity
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mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity

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