Early preclinical detection of prions in the skin of prion-infected animals

There are currently no validated methods for the diagnosis of prion disease at the preclinical stage. Here the authors show that serial protein misfolding cyclic amplification and real-time quaking-induced conversion can be used to detect prions in the skin of prion-inoculated hamsters and humanized...

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Autores principales:	Zerui Wang, Matteo Manca, Aaron Foutz, Manuel V. Camacho, Gregory J. Raymond, Brent Race, Christina D. Orru, Jue Yuan, Pingping Shen, Baiya Li, Yue Lang, Johnny Dang, Alise Adornato, Katie Williams, Nicholas R. Maurer, Pierluigi Gambetti, Bin Xu, Witold Surewicz, Robert B. Petersen, Xiaoping Dong, Brian S. Appleby, Byron Caughey, Li Cui, Qingzhong Kong, Wen-Quan Zou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce1cee2025764c18b52f904a2b45bbf1
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spelling	oai:doaj.org-article:ce1cee2025764c18b52f904a2b45bbf12021-12-02T14:35:37ZEarly preclinical detection of prions in the skin of prion-infected animals10.1038/s41467-018-08130-92041-1723https://doaj.org/article/ce1cee2025764c18b52f904a2b45bbf12019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08130-9https://doaj.org/toc/2041-1723There are currently no validated methods for the diagnosis of prion disease at the preclinical stage. Here the authors show that serial protein misfolding cyclic amplification and real-time quaking-induced conversion can be used to detect prions in the skin of prion-inoculated hamsters and humanized transgenic mice at early preclinical stages.Zerui WangMatteo MancaAaron FoutzManuel V. CamachoGregory J. RaymondBrent RaceChristina D. OrruJue YuanPingping ShenBaiya LiYue LangJohnny DangAlise AdornatoKatie WilliamsNicholas R. MaurerPierluigi GambettiBin XuWitold SurewiczRobert B. PetersenXiaoping DongBrian S. ApplebyByron CaugheyLi CuiQingzhong KongWen-Quan ZouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zerui Wang Matteo Manca Aaron Foutz Manuel V. Camacho Gregory J. Raymond Brent Race Christina D. Orru Jue Yuan Pingping Shen Baiya Li Yue Lang Johnny Dang Alise Adornato Katie Williams Nicholas R. Maurer Pierluigi Gambetti Bin Xu Witold Surewicz Robert B. Petersen Xiaoping Dong Brian S. Appleby Byron Caughey Li Cui Qingzhong Kong Wen-Quan Zou Early preclinical detection of prions in the skin of prion-infected animals
description	There are currently no validated methods for the diagnosis of prion disease at the preclinical stage. Here the authors show that serial protein misfolding cyclic amplification and real-time quaking-induced conversion can be used to detect prions in the skin of prion-inoculated hamsters and humanized transgenic mice at early preclinical stages.
format	article
author	Zerui Wang Matteo Manca Aaron Foutz Manuel V. Camacho Gregory J. Raymond Brent Race Christina D. Orru Jue Yuan Pingping Shen Baiya Li Yue Lang Johnny Dang Alise Adornato Katie Williams Nicholas R. Maurer Pierluigi Gambetti Bin Xu Witold Surewicz Robert B. Petersen Xiaoping Dong Brian S. Appleby Byron Caughey Li Cui Qingzhong Kong Wen-Quan Zou
author_facet	Zerui Wang Matteo Manca Aaron Foutz Manuel V. Camacho Gregory J. Raymond Brent Race Christina D. Orru Jue Yuan Pingping Shen Baiya Li Yue Lang Johnny Dang Alise Adornato Katie Williams Nicholas R. Maurer Pierluigi Gambetti Bin Xu Witold Surewicz Robert B. Petersen Xiaoping Dong Brian S. Appleby Byron Caughey Li Cui Qingzhong Kong Wen-Quan Zou
author_sort	Zerui Wang
title	Early preclinical detection of prions in the skin of prion-infected animals
title_short	Early preclinical detection of prions in the skin of prion-infected animals
title_full	Early preclinical detection of prions in the skin of prion-infected animals
title_fullStr	Early preclinical detection of prions in the skin of prion-infected animals
title_full_unstemmed	Early preclinical detection of prions in the skin of prion-infected animals
title_sort	early preclinical detection of prions in the skin of prion-infected animals
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ce1cee2025764c18b52f904a2b45bbf1
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Early preclinical detection of prions in the skin of prion-infected animals

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