Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments

Most mammalian genes contain alternative polyadenylation sites. Here, the authors provide evidence that mRNA can be cleaved post-transcriptionally to generate mRNAs with shorter 3-´UTRs and stable autonomous uncapped 3´-UTR sequences.

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Autores principales:	Yuval Malka, Avital Steiman-Shimony, Eran Rosenthal, Liron Argaman, Leonor Cohen-Daniel, Eliran Arbib, Hanah Margalit, Tommy Kaplan, Michael Berger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce1dad09340e458a87035489f306649d
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spelling	oai:doaj.org-article:ce1dad09340e458a87035489f306649d2021-12-02T14:42:45ZPost-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments10.1038/s41467-017-02099-72041-1723https://doaj.org/article/ce1dad09340e458a87035489f306649d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02099-7https://doaj.org/toc/2041-1723Most mammalian genes contain alternative polyadenylation sites. Here, the authors provide evidence that mRNA can be cleaved post-transcriptionally to generate mRNAs with shorter 3-´UTRs and stable autonomous uncapped 3´-UTR sequences.Yuval MalkaAvital Steiman-ShimonyEran RosenthalLiron ArgamanLeonor Cohen-DanielEliran ArbibHanah MargalitTommy KaplanMichael BergerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuval Malka Avital Steiman-Shimony Eran Rosenthal Liron Argaman Leonor Cohen-Daniel Eliran Arbib Hanah Margalit Tommy Kaplan Michael Berger Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments
description	Most mammalian genes contain alternative polyadenylation sites. Here, the authors provide evidence that mRNA can be cleaved post-transcriptionally to generate mRNAs with shorter 3-´UTRs and stable autonomous uncapped 3´-UTR sequences.
format	article
author	Yuval Malka Avital Steiman-Shimony Eran Rosenthal Liron Argaman Leonor Cohen-Daniel Eliran Arbib Hanah Margalit Tommy Kaplan Michael Berger
author_facet	Yuval Malka Avital Steiman-Shimony Eran Rosenthal Liron Argaman Leonor Cohen-Daniel Eliran Arbib Hanah Margalit Tommy Kaplan Michael Berger
author_sort	Yuval Malka
title	Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments
title_short	Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments
title_full	Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments
title_fullStr	Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments
title_full_unstemmed	Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments
title_sort	post-transcriptional 3´-utr cleavage of mrna transcripts generates thousands of stable uncapped autonomous rna fragments
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ce1dad09340e458a87035489f306649d
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Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments

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