Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

Peripheral and intraspinal feedback is required to shape and update the output of spinal networks that execute motor behavior. We report that lumbar dI2 spinal interneurons in chicks receive synaptic input from afferents and premotor neurons. These interneurons innervate contralateral premotor netwo...

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Autores principales:	Baruch Haimson, Yoav Hadas, Nimrod Bernat, Artur Kania, Monica A Daley, Yuval Cinnamon, Aharon Lev-Tov, Avihu Klar
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	spinal cord interneurons locomotion cerebellum spinocerebellar tract neural circuits Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ce1ef333e577458faa11775836128c1f
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spelling	oai:doaj.org-article:ce1ef333e577458faa11775836128c1f2021-11-24T12:25:45ZSpinal lumbar dI2 interneurons contribute to stability of bipedal stepping10.7554/eLife.620012050-084Xe62001https://doaj.org/article/ce1ef333e577458faa11775836128c1f2021-08-01T00:00:00Zhttps://elifesciences.org/articles/62001https://doaj.org/toc/2050-084XPeripheral and intraspinal feedback is required to shape and update the output of spinal networks that execute motor behavior. We report that lumbar dI2 spinal interneurons in chicks receive synaptic input from afferents and premotor neurons. These interneurons innervate contralateral premotor networks in the lumbar and brachial spinal cord, and their ascending projections innervate the cerebellum. These findings suggest that dI2 neurons function as interneurons in local lumbar circuits, are involved in lumbo-brachial coupling, and that part of them deliver peripheral and intraspinal feedback to the cerebellum. Silencing of dI2 neurons leads to destabilized stepping in posthatching day 8 hatchlings, with occasional collapses, variable step profiles, and a wide-base walking gait, suggesting that dI2 neurons may contribute to the stabilization of the bipedal gait.Baruch HaimsonYoav HadasNimrod BernatArtur KaniaMonica A DaleyYuval CinnamonAharon Lev-TovAvihu KlareLife Sciences Publications Ltdarticlespinal cordinterneuronslocomotioncerebellumspinocerebellar tractneural circuitsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord interneurons locomotion cerebellum spinocerebellar tract neural circuits Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	spinal cord interneurons locomotion cerebellum spinocerebellar tract neural circuits Medicine R Science Q Biology (General) QH301-705.5 Baruch Haimson Yoav Hadas Nimrod Bernat Artur Kania Monica A Daley Yuval Cinnamon Aharon Lev-Tov Avihu Klar Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping
description	Peripheral and intraspinal feedback is required to shape and update the output of spinal networks that execute motor behavior. We report that lumbar dI2 spinal interneurons in chicks receive synaptic input from afferents and premotor neurons. These interneurons innervate contralateral premotor networks in the lumbar and brachial spinal cord, and their ascending projections innervate the cerebellum. These findings suggest that dI2 neurons function as interneurons in local lumbar circuits, are involved in lumbo-brachial coupling, and that part of them deliver peripheral and intraspinal feedback to the cerebellum. Silencing of dI2 neurons leads to destabilized stepping in posthatching day 8 hatchlings, with occasional collapses, variable step profiles, and a wide-base walking gait, suggesting that dI2 neurons may contribute to the stabilization of the bipedal gait.
format	article
author	Baruch Haimson Yoav Hadas Nimrod Bernat Artur Kania Monica A Daley Yuval Cinnamon Aharon Lev-Tov Avihu Klar
author_facet	Baruch Haimson Yoav Hadas Nimrod Bernat Artur Kania Monica A Daley Yuval Cinnamon Aharon Lev-Tov Avihu Klar
author_sort	Baruch Haimson
title	Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping
title_short	Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping
title_full	Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping
title_fullStr	Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping
title_full_unstemmed	Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping
title_sort	spinal lumbar di2 interneurons contribute to stability of bipedal stepping
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/ce1ef333e577458faa11775836128c1f
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Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

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