Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities

Abstract The incidence of squamous cell carcinomas of the head and neck (HNSCC) is consistently increasing, in association with human papillomavirus (HPV) infection, especially HPV16. HPV variants show heterogeneity in the pathogenicity of cervical cancer, but little has been established about their...

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Autores principales:	Daniela Cochicho, Rui Gil da Costa, Ana Felix
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	HNSCC HPV16 HPV16 variants Next generation sequencing Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ce2075931cb2495cb589efeb429f7e22
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spelling	oai:doaj.org-article:ce2075931cb2495cb589efeb429f7e222021-11-14T12:05:21ZExploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities10.1186/s12985-021-01688-91743-422Xhttps://doaj.org/article/ce2075931cb2495cb589efeb429f7e222021-11-01T00:00:00Zhttps://doi.org/10.1186/s12985-021-01688-9https://doaj.org/toc/1743-422XAbstract The incidence of squamous cell carcinomas of the head and neck (HNSCC) is consistently increasing, in association with human papillomavirus (HPV) infection, especially HPV16. HPV variants show heterogeneity in the pathogenicity of cervical cancer, but little has been established about their relevance on HNSCC. This review addresses the distribution of HPV16 variants in HNSCC and their potential contribution to clinical practice. A search was performed in PubMed using the keywords HNSCC HPV16 variants. Sixty articles were identified between 2000 and 2020 and 9 articles were selected for a systematic analysis. Clinical cohorts comprised 4 to 253 patients aged between 17 and 91 years with confirmed HPV16-positive HNSCC. Samples were collected from fresh biopsies of the tumour, oral rinse or formol fixed/paraffin embedded tissue, from the oral cavity, oropharynx, hypopharynx, larynx and Waldeyer's tonsillar ring. HPV16 variants were identified using Sanger sequencing techniques. Seven studies addressed the HPV16 E6 gene, one studied E6 and E7, another studied L1 and one focused on the long control region. European variants represent 25–95%, Asian-American 5–57% and African 2–4% of the total isolates, suggesting a marked predominance of European strains. No correlations could be drawn with patient prognosis, partly because many studies relied on small patient cohorts. Additional studies are needed, particularly those employing next generation sequencing techniques (NGS), which will allow faster and accurate analysis of large numbers of samples.Daniela CochichoRui Gil da CostaAna FelixBMCarticleHNSCCHPV16HPV16 variantsNext generation sequencingInfectious and parasitic diseasesRC109-216ENVirology Journal, Vol 18, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HNSCC HPV16 HPV16 variants Next generation sequencing Infectious and parasitic diseases RC109-216
spellingShingle	HNSCC HPV16 HPV16 variants Next generation sequencing Infectious and parasitic diseases RC109-216 Daniela Cochicho Rui Gil da Costa Ana Felix Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities
description	Abstract The incidence of squamous cell carcinomas of the head and neck (HNSCC) is consistently increasing, in association with human papillomavirus (HPV) infection, especially HPV16. HPV variants show heterogeneity in the pathogenicity of cervical cancer, but little has been established about their relevance on HNSCC. This review addresses the distribution of HPV16 variants in HNSCC and their potential contribution to clinical practice. A search was performed in PubMed using the keywords HNSCC HPV16 variants. Sixty articles were identified between 2000 and 2020 and 9 articles were selected for a systematic analysis. Clinical cohorts comprised 4 to 253 patients aged between 17 and 91 years with confirmed HPV16-positive HNSCC. Samples were collected from fresh biopsies of the tumour, oral rinse or formol fixed/paraffin embedded tissue, from the oral cavity, oropharynx, hypopharynx, larynx and Waldeyer's tonsillar ring. HPV16 variants were identified using Sanger sequencing techniques. Seven studies addressed the HPV16 E6 gene, one studied E6 and E7, another studied L1 and one focused on the long control region. European variants represent 25–95%, Asian-American 5–57% and African 2–4% of the total isolates, suggesting a marked predominance of European strains. No correlations could be drawn with patient prognosis, partly because many studies relied on small patient cohorts. Additional studies are needed, particularly those employing next generation sequencing techniques (NGS), which will allow faster and accurate analysis of large numbers of samples.
format	article
author	Daniela Cochicho Rui Gil da Costa Ana Felix
author_facet	Daniela Cochicho Rui Gil da Costa Ana Felix
author_sort	Daniela Cochicho
title	Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities
title_short	Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities
title_full	Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities
title_fullStr	Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities
title_full_unstemmed	Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities
title_sort	exploring the roles of hpv16 variants in head and neck squamous cell carcinoma: current challenges and opportunities
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ce2075931cb2495cb589efeb429f7e22
work_keys_str_mv	AT danielacochicho exploringtherolesofhpv16variantsinheadandnecksquamouscellcarcinomacurrentchallengesandopportunities AT ruigildacosta exploringtherolesofhpv16variantsinheadandnecksquamouscellcarcinomacurrentchallengesandopportunities AT anafelix exploringtherolesofhpv16variantsinheadandnecksquamouscellcarcinomacurrentchallengesandopportunities
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Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities

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