B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

Dietary fiber-derived short-chain fatty acids (SCFA) act as histone deacetylase (HDAC) inhibitors on Tregs and innate immune cells, promoting immune tolerance by altering gene expression. Here the authors show that SCFA HDAC inhibitor activity impacts B cell differentiation, antibody responses and a...

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Autores principales:	Helia N. Sanchez, Justin B. Moroney, Huoqun Gan, Tian Shen, John L. Im, Tianbao Li, Julia R. Taylor, Hong Zan, Paolo Casali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce20bc7d054049c9aaae3302f0ad4e24
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spelling	oai:doaj.org-article:ce20bc7d054049c9aaae3302f0ad4e242021-12-02T15:33:53ZB cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids10.1038/s41467-019-13603-62041-1723https://doaj.org/article/ce20bc7d054049c9aaae3302f0ad4e242020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13603-6https://doaj.org/toc/2041-1723Dietary fiber-derived short-chain fatty acids (SCFA) act as histone deacetylase (HDAC) inhibitors on Tregs and innate immune cells, promoting immune tolerance by altering gene expression. Here the authors show that SCFA HDAC inhibitor activity impacts B cell differentiation, antibody responses and antibody-driven autoimmunity.Helia N. SanchezJustin B. MoroneyHuoqun GanTian ShenJohn L. ImTianbao LiJulia R. TaylorHong ZanPaolo CasaliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Helia N. Sanchez Justin B. Moroney Huoqun Gan Tian Shen John L. Im Tianbao Li Julia R. Taylor Hong Zan Paolo Casali B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
description	Dietary fiber-derived short-chain fatty acids (SCFA) act as histone deacetylase (HDAC) inhibitors on Tregs and innate immune cells, promoting immune tolerance by altering gene expression. Here the authors show that SCFA HDAC inhibitor activity impacts B cell differentiation, antibody responses and antibody-driven autoimmunity.
format	article
author	Helia N. Sanchez Justin B. Moroney Huoqun Gan Tian Shen John L. Im Tianbao Li Julia R. Taylor Hong Zan Paolo Casali
author_facet	Helia N. Sanchez Justin B. Moroney Huoqun Gan Tian Shen John L. Im Tianbao Li Julia R. Taylor Hong Zan Paolo Casali
author_sort	Helia N. Sanchez
title	B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
title_short	B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
title_full	B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
title_fullStr	B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
title_full_unstemmed	B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
title_sort	b cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ce20bc7d054049c9aaae3302f0ad4e24
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B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

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