Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling.
<h4>Aims</h4>Chewing of betel quid (BQ) increases the risk of oral cancer and oral submucous fibrosis (OSF), possibly by BQ-induced toxicity and induction of inflammatory response in oral mucosa.<h4>Methods</h4>Primary gingival keratinocytes (GK cells) were exposed to areca n...
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| Main Authors: | , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2014
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| Subjects: | |
| Online Access: | https://doaj.org/article/ce20d7ef520a48c28c9a2a36e30d8174 |
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