Gene drives in malaria control: what we need to know

Gene drives are being used to enhance a DNA sequence’s likelihood of passing between generations via sexual reproduction. Gene drives can be deployed to manipulate natural populations. They can be used to suppress populations by reducing the number of individuals in a population or to modify populat...

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Autores principales:	Reagan Mudziwapasi, Munyaradzi Christopher Changara, Abigarl Ndudzo, Tinotenda Kaseke, Farai Godobo, Floryn L. Mtemeli, Ryman Shoko, Fanuel Songwe, Sakhile Ndlovu, Sibonani Sandra Mlambo
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	plasmodium malaria mosquito control genome editing species elimination Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/ce20e485b8544e49a11a225c5335e240
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id	oai:doaj.org-article:ce20e485b8544e49a11a225c5335e240
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spelling	oai:doaj.org-article:ce20e485b8544e49a11a225c5335e2402021-11-17T14:21:55ZGene drives in malaria control: what we need to know1310-28181314-353010.1080/13102818.2021.1996269https://doaj.org/article/ce20e485b8544e49a11a225c5335e2402021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13102818.2021.1996269https://doaj.org/toc/1310-2818https://doaj.org/toc/1314-3530Gene drives are being used to enhance a DNA sequence’s likelihood of passing between generations via sexual reproduction. Gene drives can be deployed to manipulate natural populations. They can be used to suppress populations by reducing the number of individuals in a population or to modify populations. There are more than 3000 mosquito species in the world, some of which are vectors of diseases. Malaria is a typical disease whose vectors are mosquitoes. It affects mostly tropical countries. It kills many people annually, many of whom are children. Interventions currently in use, such as indoor residual spraying and mosquito nets, are proving insufficient to eradicate malaria. Gene drives can be used in different ways to control mosquito populations or to eliminate mosquito species, thereby reducing malaria cases and deaths. This can occur through population replacement or suppression. However, before the elimination of any mosquito species for malaria control, it is necessary to consider the effects of such an action. Additionally, there is a need to review the options available for the control of mosquitoes and to create awareness of the benefits and risks of such an action. This paper, therefore, looks at the role of mosquitoes in the environment, the methods of controlling mosquitoes and malaria and necessary considerations when using gene drives inter alia.Reagan MudziwapasiMunyaradzi Christopher ChangaraAbigarl NdudzoTinotenda KasekeFarai GodoboFloryn L. MtemeliRyman ShokoFanuel SongweSakhile NdlovuSibonani Sandra MlamboTaylor & Francis Grouparticleplasmodiummalariamosquito controlgenome editingspecieseliminationBiotechnologyTP248.13-248.65ENBiotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 1623-1631 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasmodium malaria mosquito control genome editing species elimination Biotechnology TP248.13-248.65
spellingShingle	plasmodium malaria mosquito control genome editing species elimination Biotechnology TP248.13-248.65 Reagan Mudziwapasi Munyaradzi Christopher Changara Abigarl Ndudzo Tinotenda Kaseke Farai Godobo Floryn L. Mtemeli Ryman Shoko Fanuel Songwe Sakhile Ndlovu Sibonani Sandra Mlambo Gene drives in malaria control: what we need to know
description	Gene drives are being used to enhance a DNA sequence’s likelihood of passing between generations via sexual reproduction. Gene drives can be deployed to manipulate natural populations. They can be used to suppress populations by reducing the number of individuals in a population or to modify populations. There are more than 3000 mosquito species in the world, some of which are vectors of diseases. Malaria is a typical disease whose vectors are mosquitoes. It affects mostly tropical countries. It kills many people annually, many of whom are children. Interventions currently in use, such as indoor residual spraying and mosquito nets, are proving insufficient to eradicate malaria. Gene drives can be used in different ways to control mosquito populations or to eliminate mosquito species, thereby reducing malaria cases and deaths. This can occur through population replacement or suppression. However, before the elimination of any mosquito species for malaria control, it is necessary to consider the effects of such an action. Additionally, there is a need to review the options available for the control of mosquitoes and to create awareness of the benefits and risks of such an action. This paper, therefore, looks at the role of mosquitoes in the environment, the methods of controlling mosquitoes and malaria and necessary considerations when using gene drives inter alia.
format	article
author	Reagan Mudziwapasi Munyaradzi Christopher Changara Abigarl Ndudzo Tinotenda Kaseke Farai Godobo Floryn L. Mtemeli Ryman Shoko Fanuel Songwe Sakhile Ndlovu Sibonani Sandra Mlambo
author_facet	Reagan Mudziwapasi Munyaradzi Christopher Changara Abigarl Ndudzo Tinotenda Kaseke Farai Godobo Floryn L. Mtemeli Ryman Shoko Fanuel Songwe Sakhile Ndlovu Sibonani Sandra Mlambo
author_sort	Reagan Mudziwapasi
title	Gene drives in malaria control: what we need to know
title_short	Gene drives in malaria control: what we need to know
title_full	Gene drives in malaria control: what we need to know
title_fullStr	Gene drives in malaria control: what we need to know
title_full_unstemmed	Gene drives in malaria control: what we need to know
title_sort	gene drives in malaria control: what we need to know
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/ce20e485b8544e49a11a225c5335e240
work_keys_str_mv	AT reaganmudziwapasi genedrivesinmalariacontrolwhatweneedtoknow AT munyaradzichristopherchangara genedrivesinmalariacontrolwhatweneedtoknow AT abigarlndudzo genedrivesinmalariacontrolwhatweneedtoknow AT tinotendakaseke genedrivesinmalariacontrolwhatweneedtoknow AT faraigodobo genedrivesinmalariacontrolwhatweneedtoknow AT florynlmtemeli genedrivesinmalariacontrolwhatweneedtoknow AT rymanshoko genedrivesinmalariacontrolwhatweneedtoknow AT fanuelsongwe genedrivesinmalariacontrolwhatweneedtoknow AT sakhilendlovu genedrivesinmalariacontrolwhatweneedtoknow AT sibonanisandramlambo genedrivesinmalariacontrolwhatweneedtoknow
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Gene drives in malaria control: what we need to know

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