The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment

Ascorbate is an important element of a variety of cellular processes including the control of reactive oxygen species levels. Since reactive oxygen species are implicated as a key factor in tumorigenesis and antitumor therapy, the injection of a large amount of ascorbate is considered beneficial in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mateusz Gąbka, Paulina Dałek, Magdalena Przybyło, Daniel Gackowski, Ryszard Oliński, Marek Langner
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamin C membrane electrical potential cancer treatment ferroptosis ascorbate efficacy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ce2240cb9f7b476a8d0735404d2f6ee7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ce2240cb9f7b476a8d0735404d2f6ee7
record_format	dspace
spelling	oai:doaj.org-article:ce2240cb9f7b476a8d0735404d2f6ee72021-11-25T17:09:52ZThe Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment10.3390/cells101129642073-4409https://doaj.org/article/ce2240cb9f7b476a8d0735404d2f6ee72021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2964https://doaj.org/toc/2073-4409Ascorbate is an important element of a variety of cellular processes including the control of reactive oxygen species levels. Since reactive oxygen species are implicated as a key factor in tumorigenesis and antitumor therapy, the injection of a large amount of ascorbate is considered beneficial in cancer therapy. Recent studies have shown that ascorbate can cross the plasma membrane through passive diffusion. In contrast to absorption by active transport, which is facilitated by transport proteins (SVCT1 and SVCT2). The passive diffusion of a weak acid across membranes depends on the electrostatic potential and the pH gradients. This has been used to construct a new theoretical model capable of providing steady-state ascorbate concentration in the intracellular space and evaluating the time needed to reach it. The main conclusion of the analysis is that the steady-state intracellular ascorbate concentration weakly depends on its serum concentration but requires days of exposure to saturate. Based on these findings, it can be hypothesized that extended oral ascorbate delivery is possibly more effective than a short intravenous infusion of high ascorbate quantities.Mateusz GąbkaPaulina DałekMagdalena PrzybyłoDaniel GackowskiRyszard OlińskiMarek LangnerMDPI AGarticlevitamin Cmembrane electrical potentialcancer treatmentferroptosisascorbate efficacyBiology (General)QH301-705.5ENCells, Vol 10, Iss 2964, p 2964 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin C membrane electrical potential cancer treatment ferroptosis ascorbate efficacy Biology (General) QH301-705.5
spellingShingle	vitamin C membrane electrical potential cancer treatment ferroptosis ascorbate efficacy Biology (General) QH301-705.5 Mateusz Gąbka Paulina Dałek Magdalena Przybyło Daniel Gackowski Ryszard Oliński Marek Langner The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment
description	Ascorbate is an important element of a variety of cellular processes including the control of reactive oxygen species levels. Since reactive oxygen species are implicated as a key factor in tumorigenesis and antitumor therapy, the injection of a large amount of ascorbate is considered beneficial in cancer therapy. Recent studies have shown that ascorbate can cross the plasma membrane through passive diffusion. In contrast to absorption by active transport, which is facilitated by transport proteins (SVCT1 and SVCT2). The passive diffusion of a weak acid across membranes depends on the electrostatic potential and the pH gradients. This has been used to construct a new theoretical model capable of providing steady-state ascorbate concentration in the intracellular space and evaluating the time needed to reach it. The main conclusion of the analysis is that the steady-state intracellular ascorbate concentration weakly depends on its serum concentration but requires days of exposure to saturate. Based on these findings, it can be hypothesized that extended oral ascorbate delivery is possibly more effective than a short intravenous infusion of high ascorbate quantities.
format	article
author	Mateusz Gąbka Paulina Dałek Magdalena Przybyło Daniel Gackowski Ryszard Oliński Marek Langner
author_facet	Mateusz Gąbka Paulina Dałek Magdalena Przybyło Daniel Gackowski Ryszard Oliński Marek Langner
author_sort	Mateusz Gąbka
title	The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment
title_short	The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment
title_full	The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment
title_fullStr	The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment
title_full_unstemmed	The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment
title_sort	membrane electrical potential and intracellular ph as factors influencing intracellular ascorbate concentration and their role in cancer treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ce2240cb9f7b476a8d0735404d2f6ee7
work_keys_str_mv	AT mateuszgabka themembraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT paulinadałek themembraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT magdalenaprzybyło themembraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT danielgackowski themembraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT ryszardolinski themembraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT mareklangner themembraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT mateuszgabka membraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT paulinadałek membraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT magdalenaprzybyło membraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT danielgackowski membraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT ryszardolinski membraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment AT mareklangner membraneelectricalpotentialandintracellularphasfactorsinfluencingintracellularascorbateconcentrationandtheirroleincancertreatment
_version_	1718412679455965184

The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment

Ejemplares similares