GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, including disease states, to imply a physiological fu...

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Autores principales: Otavio Cabral-Marques, Alexandre Marques, Lasse Melvær Giil, Roberta De Vito, Judith Rademacher, Jeannine Günther, Tanja Lange, Jens Y. Humrich, Sebastian Klapa, Susanne Schinke, Lena F. Schimke, Gabriele Marschner, Silke Pitann, Sabine Adler, Ralf Dechend, Dominik N. Müller, Ioana Braicu, Jalid Sehouli, Kai Schulze-Forster, Tobias Trippel, Carmen Scheibenbogen, Annetine Staff, Peter R. Mertens, Madlen Löbel, Justin Mastroianni, Corinna Plattfaut, Frank Gieseler, Duska Dragun, Barbara Elizabeth Engelhardt, Maria J. Fernandez-Cabezudo, Hans D. Ochs, Basel K. al-Ramadi, Peter Lamprecht, Antje Mueller, Harald Heidecke, Gabriela Riemekasten
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/ce22418439234ad18d21d372dba2db52
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Sumario:Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, including disease states, to imply a physiological function in maintaining immune homeostasis.

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