GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis
Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, including disease states, to imply a physiological fu...
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Nature Portfolio
2018
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oai:doaj.org-article:ce22418439234ad18d21d372dba2db522021-12-02T14:39:04ZGPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis10.1038/s41467-018-07598-92041-1723https://doaj.org/article/ce22418439234ad18d21d372dba2db522018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07598-9https://doaj.org/toc/2041-1723Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, including disease states, to imply a physiological function in maintaining immune homeostasis.Otavio Cabral-MarquesAlexandre MarquesLasse Melvær GiilRoberta De VitoJudith RademacherJeannine GüntherTanja LangeJens Y. HumrichSebastian KlapaSusanne SchinkeLena F. SchimkeGabriele MarschnerSilke PitannSabine AdlerRalf DechendDominik N. MüllerIoana BraicuJalid SehouliKai Schulze-ForsterTobias TrippelCarmen ScheibenbogenAnnetine StaffPeter R. MertensMadlen LöbelJustin MastroianniCorinna PlattfautFrank GieselerDuska DragunBarbara Elizabeth EngelhardtMaria J. Fernandez-CabezudoHans D. OchsBasel K. al-RamadiPeter LamprechtAntje MuellerHarald HeideckeGabriela RiemekastenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Otavio Cabral-Marques Alexandre Marques Lasse Melvær Giil Roberta De Vito Judith Rademacher Jeannine Günther Tanja Lange Jens Y. Humrich Sebastian Klapa Susanne Schinke Lena F. Schimke Gabriele Marschner Silke Pitann Sabine Adler Ralf Dechend Dominik N. Müller Ioana Braicu Jalid Sehouli Kai Schulze-Forster Tobias Trippel Carmen Scheibenbogen Annetine Staff Peter R. Mertens Madlen Löbel Justin Mastroianni Corinna Plattfaut Frank Gieseler Duska Dragun Barbara Elizabeth Engelhardt Maria J. Fernandez-Cabezudo Hans D. Ochs Basel K. al-Ramadi Peter Lamprecht Antje Mueller Harald Heidecke Gabriela Riemekasten GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis |
| description |
Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, including disease states, to imply a physiological function in maintaining immune homeostasis. |
| format |
article |
| author |
Otavio Cabral-Marques Alexandre Marques Lasse Melvær Giil Roberta De Vito Judith Rademacher Jeannine Günther Tanja Lange Jens Y. Humrich Sebastian Klapa Susanne Schinke Lena F. Schimke Gabriele Marschner Silke Pitann Sabine Adler Ralf Dechend Dominik N. Müller Ioana Braicu Jalid Sehouli Kai Schulze-Forster Tobias Trippel Carmen Scheibenbogen Annetine Staff Peter R. Mertens Madlen Löbel Justin Mastroianni Corinna Plattfaut Frank Gieseler Duska Dragun Barbara Elizabeth Engelhardt Maria J. Fernandez-Cabezudo Hans D. Ochs Basel K. al-Ramadi Peter Lamprecht Antje Mueller Harald Heidecke Gabriela Riemekasten |
| author_facet |
Otavio Cabral-Marques Alexandre Marques Lasse Melvær Giil Roberta De Vito Judith Rademacher Jeannine Günther Tanja Lange Jens Y. Humrich Sebastian Klapa Susanne Schinke Lena F. Schimke Gabriele Marschner Silke Pitann Sabine Adler Ralf Dechend Dominik N. Müller Ioana Braicu Jalid Sehouli Kai Schulze-Forster Tobias Trippel Carmen Scheibenbogen Annetine Staff Peter R. Mertens Madlen Löbel Justin Mastroianni Corinna Plattfaut Frank Gieseler Duska Dragun Barbara Elizabeth Engelhardt Maria J. Fernandez-Cabezudo Hans D. Ochs Basel K. al-Ramadi Peter Lamprecht Antje Mueller Harald Heidecke Gabriela Riemekasten |
| author_sort |
Otavio Cabral-Marques |
| title |
GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis |
| title_short |
GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis |
| title_full |
GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis |
| title_fullStr |
GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis |
| title_full_unstemmed |
GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis |
| title_sort |
gpcr-specific autoantibody signatures are associated with physiological and pathological immune homeostasis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ce22418439234ad18d21d372dba2db52 |
| work_keys_str_mv |
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