Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status

Xiaojiao Jia, Lanxiang Liu, Rui Wang, Xiaoli Liu, Binbin Liu, Ning Ma, Qiang Lu Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, People’s Republic of ChinaCorrespondence: Qiang LuDepartment of Endocrinology, The First Hospital of Qinhuangd...

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Autores principales:	Jia X, Liu L, Wang R, Liu X, Liu B, Ma N, Lu Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	abdominal visceral fat abnormal glucose metabolism two-hour plasma glucose bone mineral density bone mineral content Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ce23cf0a80894cdf9e6bbe4ee514ed14
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spelling	oai:doaj.org-article:ce23cf0a80894cdf9e6bbe4ee514ed142021-12-02T11:04:37ZRelationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status1178-7007https://doaj.org/article/ce23cf0a80894cdf9e6bbe4ee514ed142020-03-01T00:00:00Zhttps://www.dovepress.com/relationship-of-two-hour-plasma-glucose-and-abdominal-visceral-fat-wit-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xiaojiao Jia, Lanxiang Liu, Rui Wang, Xiaoli Liu, Binbin Liu, Ning Ma, Qiang Lu Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, People’s Republic of ChinaCorrespondence: Qiang LuDepartment of Endocrinology, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao 066000, Hebei Province, People’s Republic of ChinaTel +86-335-5908368Fax +86-335-3032042Email 13933552979@163.comBackground: Several studies have reported the relationship of diabetes mellitus (DM) and obesity with bone mineral density (BMD), but the conclusions remain unclear. This study aimed to provide more information for the relationship of plasma glucose and abdominal visceral fat (AVF) with BMD and bone mineral content (BMC) in women with different glucose metabolism status.Methods: Patients were screened by oral glucose tolerance test (OGTT) and were divided into three groups: normal glucose tolerance (NGT, n=132), pre-diabetes mellitus (pre-DM, n=28) and newly diagnosed type 2 DM (T2DM, n=27) groups. Plasma glucose concentrations, anthropometric measurements, body composition, and BMD were measured. Analysis of variance (ANOVA), pearson correlation, and multiple linear regression models were used to evaluate the relationship between BMD, plasma glucose, AVF, and other variables.Results: The percentage of subjects with osteoporosis or low BMD was 29.9%, and 66.7% subjects in T2DM group were significantly higher than that in the pre-DM (28.6%) and NGT (22.7%) groups (p=0.005 and p< 0.001, respectively). Both BMD at femoral neck (FN) and lumbar spine (LS) of T2DM group were lower than those in NGT group (p=0.009 and p=0.003, respectively), and BMC of T2DM group was lower than those of NGT and pre-DM groups (p< 0.001). The results of statistical analysis revealed that both two-hour plasma glucose (2-h PG) and age showed negative correlation with BMC, FN BMD, and LS BMD. AVF showed positive correlation with BMC and LS BMD. Furthermore, the lean mass (LM) showed independent positive effects on BMC.Conclusion: Our findings suggest that 1) Age is a strong negative predictor of bone mass. 2) A direct negative effect of increasing 2-h PG might be more prominent at bone mass in women. 3) A moderate increase in AVF is beneficial to bone mass, while excessive increase might be harmful. 4) LM is a positive predictor of BMC.Keywords: abdominal visceral fat, abnormal glucose metabolism, two-hour plasma glucose, bone mineral density, bone mineral contentJia XLiu LWang RLiu XLiu BMa NLu QDove Medical Pressarticleabdominal visceral fatabnormal glucose metabolismtwo-hour plasma glucosebone mineral densitybone mineral contentSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 851-858 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	abdominal visceral fat abnormal glucose metabolism two-hour plasma glucose bone mineral density bone mineral content Specialties of internal medicine RC581-951
spellingShingle	abdominal visceral fat abnormal glucose metabolism two-hour plasma glucose bone mineral density bone mineral content Specialties of internal medicine RC581-951 Jia X Liu L Wang R Liu X Liu B Ma N Lu Q Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status
description	Xiaojiao Jia, Lanxiang Liu, Rui Wang, Xiaoli Liu, Binbin Liu, Ning Ma, Qiang Lu Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, People’s Republic of ChinaCorrespondence: Qiang LuDepartment of Endocrinology, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao 066000, Hebei Province, People’s Republic of ChinaTel +86-335-5908368Fax +86-335-3032042Email 13933552979@163.comBackground: Several studies have reported the relationship of diabetes mellitus (DM) and obesity with bone mineral density (BMD), but the conclusions remain unclear. This study aimed to provide more information for the relationship of plasma glucose and abdominal visceral fat (AVF) with BMD and bone mineral content (BMC) in women with different glucose metabolism status.Methods: Patients were screened by oral glucose tolerance test (OGTT) and were divided into three groups: normal glucose tolerance (NGT, n=132), pre-diabetes mellitus (pre-DM, n=28) and newly diagnosed type 2 DM (T2DM, n=27) groups. Plasma glucose concentrations, anthropometric measurements, body composition, and BMD were measured. Analysis of variance (ANOVA), pearson correlation, and multiple linear regression models were used to evaluate the relationship between BMD, plasma glucose, AVF, and other variables.Results: The percentage of subjects with osteoporosis or low BMD was 29.9%, and 66.7% subjects in T2DM group were significantly higher than that in the pre-DM (28.6%) and NGT (22.7%) groups (p=0.005 and p< 0.001, respectively). Both BMD at femoral neck (FN) and lumbar spine (LS) of T2DM group were lower than those in NGT group (p=0.009 and p=0.003, respectively), and BMC of T2DM group was lower than those of NGT and pre-DM groups (p< 0.001). The results of statistical analysis revealed that both two-hour plasma glucose (2-h PG) and age showed negative correlation with BMC, FN BMD, and LS BMD. AVF showed positive correlation with BMC and LS BMD. Furthermore, the lean mass (LM) showed independent positive effects on BMC.Conclusion: Our findings suggest that 1) Age is a strong negative predictor of bone mass. 2) A direct negative effect of increasing 2-h PG might be more prominent at bone mass in women. 3) A moderate increase in AVF is beneficial to bone mass, while excessive increase might be harmful. 4) LM is a positive predictor of BMC.Keywords: abdominal visceral fat, abnormal glucose metabolism, two-hour plasma glucose, bone mineral density, bone mineral content
format	article
author	Jia X Liu L Wang R Liu X Liu B Ma N Lu Q
author_facet	Jia X Liu L Wang R Liu X Liu B Ma N Lu Q
author_sort	Jia X
title	Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status
title_short	Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status
title_full	Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status
title_fullStr	Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status
title_full_unstemmed	Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status
title_sort	relationship of two-hour plasma glucose and abdominal visceral fat with bone mineral density and bone mineral content in women with different glucose metabolism status
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ce23cf0a80894cdf9e6bbe4ee514ed14
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Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status

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