Relationship between microbial translocation and endothelial function in HIV infected patients.

<h4>Background</h4>Circulating levels of microbial products are increased in HIV infection, and provoke endothelial dysfunction in other disease settings.<h4>Methodology/principal findings</h4>We examined data from a cross-sectional single site study at Indiana University (In...

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Autores principales:	Emily Blodget, Changyu Shen, Grace Aldrovandi, Adrienne Rollie, Samir K Gupta, James H Stein, Michael P Dubé
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce23f084050546f888c5d32625313100
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spelling	oai:doaj.org-article:ce23f084050546f888c5d326253131002021-11-18T07:07:05ZRelationship between microbial translocation and endothelial function in HIV infected patients.1932-620310.1371/journal.pone.0042624https://doaj.org/article/ce23f084050546f888c5d326253131002012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952600/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Circulating levels of microbial products are increased in HIV infection, and provoke endothelial dysfunction in other disease settings.<h4>Methodology/principal findings</h4>We examined data from a cross-sectional single site study at Indiana University (Indiana, N = 85) and a 24- week multicenter prospective study of antiretroviral therapy (ART) initiation (ACTG 5152s, N = 75). Brachial artery flow-mediated dilation (FMD) was measured by ultrasound. Plasma lipopolysaccharide (LPS) and soluble CD14 (sCD14) levels were measured from stored specimens and correlated with FMD values using Pearson correlations. The Indiana subjects were 63% male with a mean age of 39 years and a median CD4 count of 406 cells/mm(3) (388 not on ART, 464 on ART). The 5152s subjects were 92% were male with a mean age of 35 years and a median CD4 count of 251 cells/mm(3) at entry which increased to 396 cells/mm(3) on ART. When analyzing the two cohorts individually or in combination neither sCD14 nor LPS correlated significantly with FMD. In a pre-specified subgroup analysis of the Indiana subjects receiving ART (N = 46, mean ART duration 40 months) LPS was inversely correlated with FMD (r = -0.33, p = 0.02), but not sCD14 (r = -0.01, p = 0.9). Multivariate analysis confirmed LPS as an independent predictor of FMD in this subgroup (p = 0.02).<h4>Conclusions/significance</h4>In HIV-infected individuals on prolonged ART, higher LPS levels are associated with worse endothelial function but not in untreated subjects or at 24 weeks after ART initiation. Persistent microbial translocation may contribute to arterial dysfunction and the increased cardiovascular disease risk observed in individuals on long-term ART.Emily BlodgetChangyu ShenGrace AldrovandiAdrienne RollieSamir K GuptaJames H SteinMichael P DubéPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42624 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emily Blodget Changyu Shen Grace Aldrovandi Adrienne Rollie Samir K Gupta James H Stein Michael P Dubé Relationship between microbial translocation and endothelial function in HIV infected patients.
description	<h4>Background</h4>Circulating levels of microbial products are increased in HIV infection, and provoke endothelial dysfunction in other disease settings.<h4>Methodology/principal findings</h4>We examined data from a cross-sectional single site study at Indiana University (Indiana, N = 85) and a 24- week multicenter prospective study of antiretroviral therapy (ART) initiation (ACTG 5152s, N = 75). Brachial artery flow-mediated dilation (FMD) was measured by ultrasound. Plasma lipopolysaccharide (LPS) and soluble CD14 (sCD14) levels were measured from stored specimens and correlated with FMD values using Pearson correlations. The Indiana subjects were 63% male with a mean age of 39 years and a median CD4 count of 406 cells/mm(3) (388 not on ART, 464 on ART). The 5152s subjects were 92% were male with a mean age of 35 years and a median CD4 count of 251 cells/mm(3) at entry which increased to 396 cells/mm(3) on ART. When analyzing the two cohorts individually or in combination neither sCD14 nor LPS correlated significantly with FMD. In a pre-specified subgroup analysis of the Indiana subjects receiving ART (N = 46, mean ART duration 40 months) LPS was inversely correlated with FMD (r = -0.33, p = 0.02), but not sCD14 (r = -0.01, p = 0.9). Multivariate analysis confirmed LPS as an independent predictor of FMD in this subgroup (p = 0.02).<h4>Conclusions/significance</h4>In HIV-infected individuals on prolonged ART, higher LPS levels are associated with worse endothelial function but not in untreated subjects or at 24 weeks after ART initiation. Persistent microbial translocation may contribute to arterial dysfunction and the increased cardiovascular disease risk observed in individuals on long-term ART.
format	article
author	Emily Blodget Changyu Shen Grace Aldrovandi Adrienne Rollie Samir K Gupta James H Stein Michael P Dubé
author_facet	Emily Blodget Changyu Shen Grace Aldrovandi Adrienne Rollie Samir K Gupta James H Stein Michael P Dubé
author_sort	Emily Blodget
title	Relationship between microbial translocation and endothelial function in HIV infected patients.
title_short	Relationship between microbial translocation and endothelial function in HIV infected patients.
title_full	Relationship between microbial translocation and endothelial function in HIV infected patients.
title_fullStr	Relationship between microbial translocation and endothelial function in HIV infected patients.
title_full_unstemmed	Relationship between microbial translocation and endothelial function in HIV infected patients.
title_sort	relationship between microbial translocation and endothelial function in hiv infected patients.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ce23f084050546f888c5d32625313100
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Relationship between microbial translocation and endothelial function in HIV infected patients.

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