FREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS

This article presents a detailed description of shifts in subsets of blood lymphocyte subpopulations associated with development of the corneal ulcerative lesions as well as during penetrating keratoplasty.We have revealed some general changes typical for patients with corneal ulcer and patients wit...

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Autores principales:	I. G. Kulikova, N. V. Balatskaya, L. A. Kovaleva, P. V. Makarov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	lymphocytes phenotype blood corneal ulcer (helcoma) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ce2482ccc5c244eeae5075f3be3f4e74
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spelling	oai:doaj.org-article:ce2482ccc5c244eeae5075f3be3f4e742021-11-18T08:03:47ZFREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS1563-06252313-741X10.15789/1563-0625-2018-2-263-270https://doaj.org/article/ce2482ccc5c244eeae5075f3be3f4e742018-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1481https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThis article presents a detailed description of shifts in subsets of blood lymphocyte subpopulations associated with development of the corneal ulcerative lesions as well as during penetrating keratoplasty.We have revealed some general changes typical for patients with corneal ulcer and patients with keratoplasty, reflecting inflammatory activity, i.e., a significant increase in the numbers of lymphocytes (CD45+), relative and absolute contents of the T-cell population (CD3+), CD3+ CD4+ subpopulation, and B-lymphocytes (CD19+), as compared with the control group. A statistically significant increase in natural killer cells (СD16+СD56+) proved to be a distinctive feature of the group with keratoplasty.When analyzing mean values of CD4+/CD8+ cells from the patients with corneal ulcer, there was no statistically significant difference between the clinical groups studied. However, individual comparison of nature and frequency of CD4+/CD8+ shifts among the patients with «high» index allowed qualitative separation of the third group (severe corneal ulcer): a severe imbalance of main T-cell subpopulations was detected 2.4 times significantly more often than in the group of patients with mild forms of corneal ulcers.The obtained data are important for understanding pathogenesis of centrally localized corneal ulcer, and should be taken into account when predicting and developing a differentiated approach to the treatment of the disease.I. G. KulikovaN. V. BalatskayaL. A. KovalevaP. V. MakarovSPb RAACIarticlelymphocytesphenotypebloodcorneal ulcer (helcoma)Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 2, Pp 263-270 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocytes phenotype blood corneal ulcer (helcoma) Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocytes phenotype blood corneal ulcer (helcoma) Immunologic diseases. Allergy RC581-607 I. G. Kulikova N. V. Balatskaya L. A. Kovaleva P. V. Makarov FREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS
description	This article presents a detailed description of shifts in subsets of blood lymphocyte subpopulations associated with development of the corneal ulcerative lesions as well as during penetrating keratoplasty.We have revealed some general changes typical for patients with corneal ulcer and patients with keratoplasty, reflecting inflammatory activity, i.e., a significant increase in the numbers of lymphocytes (CD45+), relative and absolute contents of the T-cell population (CD3+), CD3+ CD4+ subpopulation, and B-lymphocytes (CD19+), as compared with the control group. A statistically significant increase in natural killer cells (СD16+СD56+) proved to be a distinctive feature of the group with keratoplasty.When analyzing mean values of CD4+/CD8+ cells from the patients with corneal ulcer, there was no statistically significant difference between the clinical groups studied. However, individual comparison of nature and frequency of CD4+/CD8+ shifts among the patients with «high» index allowed qualitative separation of the third group (severe corneal ulcer): a severe imbalance of main T-cell subpopulations was detected 2.4 times significantly more often than in the group of patients with mild forms of corneal ulcers.The obtained data are important for understanding pathogenesis of centrally localized corneal ulcer, and should be taken into account when predicting and developing a differentiated approach to the treatment of the disease.
format	article
author	I. G. Kulikova N. V. Balatskaya L. A. Kovaleva P. V. Makarov
author_facet	I. G. Kulikova N. V. Balatskaya L. A. Kovaleva P. V. Makarov
author_sort	I. G. Kulikova
title	FREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS
title_short	FREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS
title_full	FREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS
title_fullStr	FREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS
title_full_unstemmed	FREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS
title_sort	frequency of deviations from normal values in the blood subpopulations’ profile in the patients with central corneal ulcers
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/ce2482ccc5c244eeae5075f3be3f4e74
work_keys_str_mv	AT igkulikova frequencyofdeviationsfromnormalvaluesinthebloodsubpopulationsprofileinthepatientswithcentralcornealulcers AT nvbalatskaya frequencyofdeviationsfromnormalvaluesinthebloodsubpopulationsprofileinthepatientswithcentralcornealulcers AT lakovaleva frequencyofdeviationsfromnormalvaluesinthebloodsubpopulationsprofileinthepatientswithcentralcornealulcers AT pvmakarov frequencyofdeviationsfromnormalvaluesinthebloodsubpopulationsprofileinthepatientswithcentralcornealulcers
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FREQUENCY OF DEVIATIONS FROM NORMAL VALUES IN THE BLOOD SUBPOPULATIONS’ PROFILE IN THE PATIENTS WITH CENTRAL CORNEAL ULCERS

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