Fetal lung C4BPA induces p100 processing in human placenta

Abstract The non-canonical NF-κB signaling may be a central integrator of a placental clock that governs the length of human pregnancy. We sought to identify fetal signals that could activate this NF-κB pathway in the placenta, and in turn, contribute to the onset of labor. Proteomics analysis of ex...

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Autores principales:	Mayra Cruz Ithier, Nataliya Parobchak, Stacy Yadava, Jerry Cheng, Bingbing Wang, Todd Rosen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce25bda40c1c46b8a4cb3b799bb23b12
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spelling	oai:doaj.org-article:ce25bda40c1c46b8a4cb3b799bb23b122021-12-02T15:08:46ZFetal lung C4BPA induces p100 processing in human placenta10.1038/s41598-019-42078-02045-2322https://doaj.org/article/ce25bda40c1c46b8a4cb3b799bb23b122019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-42078-0https://doaj.org/toc/2045-2322Abstract The non-canonical NF-κB signaling may be a central integrator of a placental clock that governs the length of human pregnancy. We sought to identify fetal signals that could activate this NF-κB pathway in the placenta, and in turn, contribute to the onset of labor. Proteomics analysis of exosomes purified from fetal cord arterial blood revealed a total of 328 proteins, among which 48 were more significantly abundant (p < 0.01) in samples from women who delivered following elective Cesarean-section at term (39 to 40 weeks of estimated gestational age, EGA) compared to those who had elective Cesarean deliveries near term (35 to 36 weeks of EGA). Computational, crystal structural, and gene functional analyses showed that one of these 48 proteins, C4BPA, binds to CD40 of placental villous trophoblast to activate p100 processing to p52, and in turn, pro-labor genes. These results suggest that fetal C4BPA-induced activation of non-canonical NF-κB in human placenta may play a critical role in processes of term or preterm labor.Mayra Cruz IthierNataliya ParobchakStacy YadavaJerry ChengBingbing WangTodd RosenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mayra Cruz Ithier Nataliya Parobchak Stacy Yadava Jerry Cheng Bingbing Wang Todd Rosen Fetal lung C4BPA induces p100 processing in human placenta
description	Abstract The non-canonical NF-κB signaling may be a central integrator of a placental clock that governs the length of human pregnancy. We sought to identify fetal signals that could activate this NF-κB pathway in the placenta, and in turn, contribute to the onset of labor. Proteomics analysis of exosomes purified from fetal cord arterial blood revealed a total of 328 proteins, among which 48 were more significantly abundant (p < 0.01) in samples from women who delivered following elective Cesarean-section at term (39 to 40 weeks of estimated gestational age, EGA) compared to those who had elective Cesarean deliveries near term (35 to 36 weeks of EGA). Computational, crystal structural, and gene functional analyses showed that one of these 48 proteins, C4BPA, binds to CD40 of placental villous trophoblast to activate p100 processing to p52, and in turn, pro-labor genes. These results suggest that fetal C4BPA-induced activation of non-canonical NF-κB in human placenta may play a critical role in processes of term or preterm labor.
format	article
author	Mayra Cruz Ithier Nataliya Parobchak Stacy Yadava Jerry Cheng Bingbing Wang Todd Rosen
author_facet	Mayra Cruz Ithier Nataliya Parobchak Stacy Yadava Jerry Cheng Bingbing Wang Todd Rosen
author_sort	Mayra Cruz Ithier
title	Fetal lung C4BPA induces p100 processing in human placenta
title_short	Fetal lung C4BPA induces p100 processing in human placenta
title_full	Fetal lung C4BPA induces p100 processing in human placenta
title_fullStr	Fetal lung C4BPA induces p100 processing in human placenta
title_full_unstemmed	Fetal lung C4BPA induces p100 processing in human placenta
title_sort	fetal lung c4bpa induces p100 processing in human placenta
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ce25bda40c1c46b8a4cb3b799bb23b12
work_keys_str_mv	AT mayracruzithier fetallungc4bpainducesp100processinginhumanplacenta AT nataliyaparobchak fetallungc4bpainducesp100processinginhumanplacenta AT stacyyadava fetallungc4bpainducesp100processinginhumanplacenta AT jerrycheng fetallungc4bpainducesp100processinginhumanplacenta AT bingbingwang fetallungc4bpainducesp100processinginhumanplacenta AT toddrosen fetallungc4bpainducesp100processinginhumanplacenta
_version_	1718388028224831488

Fetal lung C4BPA induces p100 processing in human placenta

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