Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention

Background: A total colectomy and a frequent life-long endoscopic surveillance are guaranteed to patients with Familial Adenomatous Polyposis (FAP) to reduce their risk of duodenal and rectal stump cancers. However, after surgery, individuals with FAP suffer from an increased number of diarrheal dis...

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Autores principales:	Ciniselli Chiara Maura, Bruno Eleonora, Oliverio Andreina, Baldassari Ivan, Pastori Marta, Signoroni Stefano, Vitellaro Marco, Ricci Maria Teresa, Milione Massimo, Cattaneo Laura, Gariboldi Manuela, Mancini Andrea, Rivoltini Licia, Morelli Daniele, Pasanisi Patrizia, Verderio Paolo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	FAP individuals Mediterranean low-inflammatory diet dietary questionnaires dietary adherence diarrheal discharges Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ce2752d2e3ee4f2cad67d9c16afe1159
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spelling	oai:doaj.org-article:ce2752d2e3ee4f2cad67d9c16afe11592021-11-25T18:35:50ZManagement of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention10.3390/nu131139882072-6643https://doaj.org/article/ce2752d2e3ee4f2cad67d9c16afe11592021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3988https://doaj.org/toc/2072-6643Background: A total colectomy and a frequent life-long endoscopic surveillance are guaranteed to patients with Familial Adenomatous Polyposis (FAP) to reduce their risk of duodenal and rectal stump cancers. However, after surgery, individuals with FAP suffer from an increased number of diarrheal discharges that force them to dietary restrictions. A non-randomized pilot study was conducted to assess whether a three-month low-inflammatory Mediterranean dietary intervention reduces gastro-intestinal markers of inflammation in FAP individuals. The aim of the present work is to evaluate the participant’s adherence to the proposed dietary recommendations and the change in their number of diarrheal discharges. Methods: 26 FAP individuals aged >18 years, who underwent a total colectomy with ileo-rectal anastomosis and were involved in the surveillance program at the Fondazione IRCCS Istituto Nazionale Tumori of Milan, were included in the present analysis. Results: FAP individuals significantly reduced the <i>Not recommended</i> foods (<i>p</i>-value: 0.002) and increased the consumption of the <i>Recommended</i> ones (<i>p</i>-value: 0.075). The adherence to the proposed dietary recommendations was accompanied by a significant decrease in the number of diarrheal discharges (<i>p</i>-value: 0.008). Conclusions: This study suggests that adhering to a low-inflammatory Mediterranean diet has a potential protective effect on the number of diarrheal discharges in FAP individuals.Ciniselli Chiara MauraBruno EleonoraOliverio AndreinaBaldassari IvanPastori MartaSignoroni StefanoVitellaro MarcoRicci Maria TeresaMilione MassimoCattaneo LauraGariboldi ManuelaMancini AndreaRivoltini LiciaMorelli DanielePasanisi PatriziaVerderio PaoloMDPI AGarticleFAP individualsMediterranean low-inflammatory dietdietary questionnairesdietary adherencediarrheal dischargesNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3988, p 3988 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FAP individuals Mediterranean low-inflammatory diet dietary questionnaires dietary adherence diarrheal discharges Nutrition. Foods and food supply TX341-641
spellingShingle	FAP individuals Mediterranean low-inflammatory diet dietary questionnaires dietary adherence diarrheal discharges Nutrition. Foods and food supply TX341-641 Ciniselli Chiara Maura Bruno Eleonora Oliverio Andreina Baldassari Ivan Pastori Marta Signoroni Stefano Vitellaro Marco Ricci Maria Teresa Milione Massimo Cattaneo Laura Gariboldi Manuela Mancini Andrea Rivoltini Licia Morelli Daniele Pasanisi Patrizia Verderio Paolo Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention
description	Background: A total colectomy and a frequent life-long endoscopic surveillance are guaranteed to patients with Familial Adenomatous Polyposis (FAP) to reduce their risk of duodenal and rectal stump cancers. However, after surgery, individuals with FAP suffer from an increased number of diarrheal discharges that force them to dietary restrictions. A non-randomized pilot study was conducted to assess whether a three-month low-inflammatory Mediterranean dietary intervention reduces gastro-intestinal markers of inflammation in FAP individuals. The aim of the present work is to evaluate the participant’s adherence to the proposed dietary recommendations and the change in their number of diarrheal discharges. Methods: 26 FAP individuals aged >18 years, who underwent a total colectomy with ileo-rectal anastomosis and were involved in the surveillance program at the Fondazione IRCCS Istituto Nazionale Tumori of Milan, were included in the present analysis. Results: FAP individuals significantly reduced the <i>Not recommended</i> foods (<i>p</i>-value: 0.002) and increased the consumption of the <i>Recommended</i> ones (<i>p</i>-value: 0.075). The adherence to the proposed dietary recommendations was accompanied by a significant decrease in the number of diarrheal discharges (<i>p</i>-value: 0.008). Conclusions: This study suggests that adhering to a low-inflammatory Mediterranean diet has a potential protective effect on the number of diarrheal discharges in FAP individuals.
format	article
author	Ciniselli Chiara Maura Bruno Eleonora Oliverio Andreina Baldassari Ivan Pastori Marta Signoroni Stefano Vitellaro Marco Ricci Maria Teresa Milione Massimo Cattaneo Laura Gariboldi Manuela Mancini Andrea Rivoltini Licia Morelli Daniele Pasanisi Patrizia Verderio Paolo
author_facet	Ciniselli Chiara Maura Bruno Eleonora Oliverio Andreina Baldassari Ivan Pastori Marta Signoroni Stefano Vitellaro Marco Ricci Maria Teresa Milione Massimo Cattaneo Laura Gariboldi Manuela Mancini Andrea Rivoltini Licia Morelli Daniele Pasanisi Patrizia Verderio Paolo
author_sort	Ciniselli Chiara Maura
title	Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention
title_short	Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention
title_full	Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention
title_fullStr	Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention
title_full_unstemmed	Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention
title_sort	management of dietary habits and diarrhea in fap individuals: a mediterranean low-inflammatory dietary intervention
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ce2752d2e3ee4f2cad67d9c16afe1159
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Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention

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