PRMT5 inhibition disrupts splicing and stemness in glioblastoma
The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a usefu...
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Nature Portfolio
2021
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oai:doaj.org-article:ce276d7ef43841fc91a953ffc3d02ecd2021-12-02T14:11:09ZPRMT5 inhibition disrupts splicing and stemness in glioblastoma10.1038/s41467-021-21204-52041-1723https://doaj.org/article/ce276d7ef43841fc91a953ffc3d02ecd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21204-5https://doaj.org/toc/2041-1723The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategyPatty SachamitrJolene C. HoFelipe E. CiamponiWail Ba-AlawiFiona J. CoutinhoPaul GuilhamonMichelle M. KushidaFlorence M. G. CavalliLilian LeeNaghmeh RastegarVictoria VuMaría Sánchez-OsunaJasmin Coulombe-HuntingtonEvgeny KanshinHeather WhetstoneMathieu DurandPhilippe ThibaultKirsten HartMaria MangosJoseph VeyhlWenjun ChenNhat TranBang-Chi DuongAhmed M. AmanXinghui CheXiaoyang LanOwen WhitleyOlga ZaslaverDalia Barsyte-LovejoyLaura M. RichardsIan RestallAmy CaudyHannes L. RöstZahid Quyoom BondayMark BernsteinSunit DasMichael D. CusimanoJulian SpearsGary D. BaderTrevor J. PughMike TyersMathieu LupienBenjamin Haibe-KainsH. Artee LuchmanSamuel WeissKatlin B. MassirerPanagiotis PrinosCheryl H. ArrowsmithPeter B. DirksNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Patty Sachamitr Jolene C. Ho Felipe E. Ciamponi Wail Ba-Alawi Fiona J. Coutinho Paul Guilhamon Michelle M. Kushida Florence M. G. Cavalli Lilian Lee Naghmeh Rastegar Victoria Vu María Sánchez-Osuna Jasmin Coulombe-Huntington Evgeny Kanshin Heather Whetstone Mathieu Durand Philippe Thibault Kirsten Hart Maria Mangos Joseph Veyhl Wenjun Chen Nhat Tran Bang-Chi Duong Ahmed M. Aman Xinghui Che Xiaoyang Lan Owen Whitley Olga Zaslaver Dalia Barsyte-Lovejoy Laura M. Richards Ian Restall Amy Caudy Hannes L. Röst Zahid Quyoom Bonday Mark Bernstein Sunit Das Michael D. Cusimano Julian Spears Gary D. Bader Trevor J. Pugh Mike Tyers Mathieu Lupien Benjamin Haibe-Kains H. Artee Luchman Samuel Weiss Katlin B. Massirer Panagiotis Prinos Cheryl H. Arrowsmith Peter B. Dirks PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| description |
The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategy |
| format |
article |
| author |
Patty Sachamitr Jolene C. Ho Felipe E. Ciamponi Wail Ba-Alawi Fiona J. Coutinho Paul Guilhamon Michelle M. Kushida Florence M. G. Cavalli Lilian Lee Naghmeh Rastegar Victoria Vu María Sánchez-Osuna Jasmin Coulombe-Huntington Evgeny Kanshin Heather Whetstone Mathieu Durand Philippe Thibault Kirsten Hart Maria Mangos Joseph Veyhl Wenjun Chen Nhat Tran Bang-Chi Duong Ahmed M. Aman Xinghui Che Xiaoyang Lan Owen Whitley Olga Zaslaver Dalia Barsyte-Lovejoy Laura M. Richards Ian Restall Amy Caudy Hannes L. Röst Zahid Quyoom Bonday Mark Bernstein Sunit Das Michael D. Cusimano Julian Spears Gary D. Bader Trevor J. Pugh Mike Tyers Mathieu Lupien Benjamin Haibe-Kains H. Artee Luchman Samuel Weiss Katlin B. Massirer Panagiotis Prinos Cheryl H. Arrowsmith Peter B. Dirks |
| author_facet |
Patty Sachamitr Jolene C. Ho Felipe E. Ciamponi Wail Ba-Alawi Fiona J. Coutinho Paul Guilhamon Michelle M. Kushida Florence M. G. Cavalli Lilian Lee Naghmeh Rastegar Victoria Vu María Sánchez-Osuna Jasmin Coulombe-Huntington Evgeny Kanshin Heather Whetstone Mathieu Durand Philippe Thibault Kirsten Hart Maria Mangos Joseph Veyhl Wenjun Chen Nhat Tran Bang-Chi Duong Ahmed M. Aman Xinghui Che Xiaoyang Lan Owen Whitley Olga Zaslaver Dalia Barsyte-Lovejoy Laura M. Richards Ian Restall Amy Caudy Hannes L. Röst Zahid Quyoom Bonday Mark Bernstein Sunit Das Michael D. Cusimano Julian Spears Gary D. Bader Trevor J. Pugh Mike Tyers Mathieu Lupien Benjamin Haibe-Kains H. Artee Luchman Samuel Weiss Katlin B. Massirer Panagiotis Prinos Cheryl H. Arrowsmith Peter B. Dirks |
| author_sort |
Patty Sachamitr |
| title |
PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_short |
PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_full |
PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_fullStr |
PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_full_unstemmed |
PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_sort |
prmt5 inhibition disrupts splicing and stemness in glioblastoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ce276d7ef43841fc91a953ffc3d02ecd |
| work_keys_str_mv |
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