Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults

Throughout adulthood, the brain undergoes an array of structural and functional changes during the typical aging process. These changes involve decreased brain volume, reduced synaptic density, and alterations in white matter (WM). Although there have been some previous neuroimaging studies that hav...

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Autores principales:	Benjamin Yeske, Jiancheng Hou, Nagesh Adluru, Veena A. Nair, Vivek Prabhakaran
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diffusion tensor imaging (DTI) aging tract-based spatial statistics (TBSS) white matter integrity verbal fluency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/ce288b2149424d9eb20b0bdc672a058c
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spelling	oai:doaj.org-article:ce288b2149424d9eb20b0bdc672a058c2021-11-30T10:05:07ZDifferences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults1663-436510.3389/fnagi.2021.750621https://doaj.org/article/ce288b2149424d9eb20b0bdc672a058c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.750621/fullhttps://doaj.org/toc/1663-4365Throughout adulthood, the brain undergoes an array of structural and functional changes during the typical aging process. These changes involve decreased brain volume, reduced synaptic density, and alterations in white matter (WM). Although there have been some previous neuroimaging studies that have measured the ability of adult language production and its correlations to brain function, structural gray matter volume, and functional differences between young and old adults, the structural role of WM in adult language production in individuals across the life span remains to be thoroughly elucidated. This study selected 38 young adults and 35 old adults for diffusion tensor imaging (DTI) and performed the Controlled Oral Word Association Test to assess verbal fluency (VF). Tract-Based Spatial Statistics were employed to evaluate the voxel-based group differences of diffusion metrics for the values of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and local diffusion homogeneity (LDH) in 12 WM regions of interest associated with language production. To investigate group differences on each DTI metric, an analysis of covariance (ANCOVA) controlling for sex and education level was performed, and the statistical threshold was considered at p < 0.00083 (0.05/60 labels) after Bonferroni correction for multiple comparisons. Significant differences in DTI metrics identified in the ANCOVA were used to perform correlation analyses with VF scores. Compared to the old adults, the young adults had significantly (1) increased FA values on the bilateral anterior corona radiata (ACR); (2) decreased MD values on the right ACR, but increased MD on the left uncinate fasciculus (UF); and (3) decreased RD on the bilateral ACR. There were no significant differences between the groups for AD or LDH. Moreover, the old adults had only a significant correlation between the VF score and the MD on the left UF. There were no significant correlations between VF score and DTI metrics in the young adults. This study adds to the growing body of research that WM areas involved in language production are sensitive to aging.Benjamin YeskeJiancheng HouJiancheng HouNagesh AdluruNagesh AdluruVeena A. NairVivek PrabhakaranVivek PrabhakaranVivek PrabhakaranFrontiers Media S.A.articlediffusion tensor imaging (DTI)agingtract-based spatial statistics (TBSS)white matter integrityverbal fluencyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diffusion tensor imaging (DTI) aging tract-based spatial statistics (TBSS) white matter integrity verbal fluency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	diffusion tensor imaging (DTI) aging tract-based spatial statistics (TBSS) white matter integrity verbal fluency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Benjamin Yeske Jiancheng Hou Jiancheng Hou Nagesh Adluru Nagesh Adluru Veena A. Nair Vivek Prabhakaran Vivek Prabhakaran Vivek Prabhakaran Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults
description	Throughout adulthood, the brain undergoes an array of structural and functional changes during the typical aging process. These changes involve decreased brain volume, reduced synaptic density, and alterations in white matter (WM). Although there have been some previous neuroimaging studies that have measured the ability of adult language production and its correlations to brain function, structural gray matter volume, and functional differences between young and old adults, the structural role of WM in adult language production in individuals across the life span remains to be thoroughly elucidated. This study selected 38 young adults and 35 old adults for diffusion tensor imaging (DTI) and performed the Controlled Oral Word Association Test to assess verbal fluency (VF). Tract-Based Spatial Statistics were employed to evaluate the voxel-based group differences of diffusion metrics for the values of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and local diffusion homogeneity (LDH) in 12 WM regions of interest associated with language production. To investigate group differences on each DTI metric, an analysis of covariance (ANCOVA) controlling for sex and education level was performed, and the statistical threshold was considered at p < 0.00083 (0.05/60 labels) after Bonferroni correction for multiple comparisons. Significant differences in DTI metrics identified in the ANCOVA were used to perform correlation analyses with VF scores. Compared to the old adults, the young adults had significantly (1) increased FA values on the bilateral anterior corona radiata (ACR); (2) decreased MD values on the right ACR, but increased MD on the left uncinate fasciculus (UF); and (3) decreased RD on the bilateral ACR. There were no significant differences between the groups for AD or LDH. Moreover, the old adults had only a significant correlation between the VF score and the MD on the left UF. There were no significant correlations between VF score and DTI metrics in the young adults. This study adds to the growing body of research that WM areas involved in language production are sensitive to aging.
format	article
author	Benjamin Yeske Jiancheng Hou Jiancheng Hou Nagesh Adluru Nagesh Adluru Veena A. Nair Vivek Prabhakaran Vivek Prabhakaran Vivek Prabhakaran
author_facet	Benjamin Yeske Jiancheng Hou Jiancheng Hou Nagesh Adluru Nagesh Adluru Veena A. Nair Vivek Prabhakaran Vivek Prabhakaran Vivek Prabhakaran
author_sort	Benjamin Yeske
title	Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults
title_short	Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults
title_full	Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults
title_fullStr	Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults
title_full_unstemmed	Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults
title_sort	differences in diffusion tensor imaging white matter integrity related to verbal fluency between young and old adults
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ce288b2149424d9eb20b0bdc672a058c
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Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults

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