Sustained micellar delivery via inducible transitions in nanostructure morphology

Nanocarrier administration is often performed via intermittent bolus injection while sustained delivery platforms are rarely reported. Here the authors demonstrate that the cylinder-to-sphere transitions of self-assembled filomicelle scaffolds can be used for sustained delivery with improved resorpt...

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Bibliographic Details
Main Authors: Nicholas B. Karabin, Sean Allen, Ha-Kyung Kwon, Sharan Bobbala, Emre Firlar, Tolou Shokuhfar, Kenneth R. Shull, Evan A. Scott
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/ce2bb2bc8ef841a2af53aed925aacee2
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Summary:Nanocarrier administration is often performed via intermittent bolus injection while sustained delivery platforms are rarely reported. Here the authors demonstrate that the cylinder-to-sphere transitions of self-assembled filomicelle scaffolds can be used for sustained delivery with improved resorptive capacity and biocompatibility.