A Microbial Association with Autism

ABSTRACT Autism is a heterogeneous group of complex developmental disabilities that result from a number of possible etiologies. There are a well-known number of comorbidities associated with autism spectrum disorders (ASD), including, commonly, gastrointestinal (GI) pathology, which can include var...

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Autores principales:	Jorge L. Benach, Ellen Li, Margaret M. McGovern
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ce2d530f38984abcb7323e4b8ecb40f7
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spelling	oai:doaj.org-article:ce2d530f38984abcb7323e4b8ecb40f72021-11-15T15:39:03ZA Microbial Association with Autism10.1128/mBio.00019-122150-7511https://doaj.org/article/ce2d530f38984abcb7323e4b8ecb40f72012-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00019-12https://doaj.org/toc/2150-7511ABSTRACT Autism is a heterogeneous group of complex developmental disabilities that result from a number of possible etiologies. There are a well-known number of comorbidities associated with autism spectrum disorders (ASD), including, commonly, gastrointestinal (GI) pathology, which can include variable combinations of constipation, diarrhea, abdominal pain, gastroesophageal reflux, and vomiting. An American Academy of Pediatrics consensus panel has recommended that prospective studies be carried out to determine the prevalence of GI disorders in ASD and their pathophysiologic basis. In a recent article, Williams et al. [B. L. Williams, M. Hornig, T. Parekh, and W. I. Lipkin, mBio 3(1):e00261-11, 2012] have provided one such study of autism with GI comorbidities by presenting evidence of Sutterella species in ileal mucosal biopsy specimens from patients diagnosed with ASD but not in control children with GI symptoms, suggesting a specific role for Sutterella in ASD. Sutterella sequences represented ~1 to 7% of the total bacterial sequences, and this is a very large effect size on the ileal mucosal composition of the autism phenotype, rivaling or perhaps exceeding the effect size of the ileal Crohn’s disease phenotype. This study opens a new field of investigation to study the etiology or consequences of GI comorbidities in ASD.Jorge L. BenachEllen LiMargaret M. McGovernAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 1 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jorge L. Benach Ellen Li Margaret M. McGovern A Microbial Association with Autism
description	ABSTRACT Autism is a heterogeneous group of complex developmental disabilities that result from a number of possible etiologies. There are a well-known number of comorbidities associated with autism spectrum disorders (ASD), including, commonly, gastrointestinal (GI) pathology, which can include variable combinations of constipation, diarrhea, abdominal pain, gastroesophageal reflux, and vomiting. An American Academy of Pediatrics consensus panel has recommended that prospective studies be carried out to determine the prevalence of GI disorders in ASD and their pathophysiologic basis. In a recent article, Williams et al. [B. L. Williams, M. Hornig, T. Parekh, and W. I. Lipkin, mBio 3(1):e00261-11, 2012] have provided one such study of autism with GI comorbidities by presenting evidence of Sutterella species in ileal mucosal biopsy specimens from patients diagnosed with ASD but not in control children with GI symptoms, suggesting a specific role for Sutterella in ASD. Sutterella sequences represented ~1 to 7% of the total bacterial sequences, and this is a very large effect size on the ileal mucosal composition of the autism phenotype, rivaling or perhaps exceeding the effect size of the ileal Crohn’s disease phenotype. This study opens a new field of investigation to study the etiology or consequences of GI comorbidities in ASD.
format	article
author	Jorge L. Benach Ellen Li Margaret M. McGovern
author_facet	Jorge L. Benach Ellen Li Margaret M. McGovern
author_sort	Jorge L. Benach
title	A Microbial Association with Autism
title_short	A Microbial Association with Autism
title_full	A Microbial Association with Autism
title_fullStr	A Microbial Association with Autism
title_full_unstemmed	A Microbial Association with Autism
title_sort	microbial association with autism
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/ce2d530f38984abcb7323e4b8ecb40f7
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A Microbial Association with Autism

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