Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition

Abstract Here, a Selenium-enriched Bacillus subtilis (SEBS) strain was generated and supplemented to broiler chickens’ diet, and the impact in ileum bacterial microbiome, immunity and body weight were assessed. In a nutshell, five hundred 1-old old chicken were randomly divided into five groups: con...

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Autores principales:	Jiajun Yang, Jing Wang, Kehe Huang, Qingxin Liu, GuofangLiu, Xiaozhou Xu, Hao Zhang, Mengling Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce2d748f7dde42e5885289cf8c2977ac
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spelling	oai:doaj.org-article:ce2d748f7dde42e5885289cf8c2977ac2021-11-08T10:50:47ZSelenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition10.1038/s41598-021-00699-42045-2322https://doaj.org/article/ce2d748f7dde42e5885289cf8c2977ac2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00699-4https://doaj.org/toc/2045-2322Abstract Here, a Selenium-enriched Bacillus subtilis (SEBS) strain was generated and supplemented to broiler chickens’ diet, and the impact in ileum bacterial microbiome, immunity and body weight were assessed. In a nutshell, five hundred 1-old old chicken were randomly divided into five groups: control, inorganic Se, Bacillus subtilis (B. subtilis), SEBS, and antibiotic, and colonization with B. subtilis and SEBS in the gastrointestinal tract (GIT) were measured by fluorescence in situ hybridization (FISH) assay and quantitative real-time polymerase chain reaction (qPCR). In summary, Chicks fed SEBS or B. subtilis had higher body weight than the control chicks or those given inorganic Se. SEBS colonized in distal segments of the ileum improved bacterial diversity, reduced the endogenous pathogen burden and increased the number of Lactobacillus sp. in the ileal mucous membrane. Species of unclassified Lachnospiraceae, uncultured Anaerosporobacter, Peptococcus, Lactobacillus salivarius, and Ruminococcaceae_UCG-014, and unclassified Butyricicoccus in the ileal mucous membrane played a key role in promoting immunity. Inorganic Se supplementation also improved bacterial composition of ileal mucous membranes, but to a less extent. In conclusion, SEBS improved performance and immunity of broiler chickens through colonization and modulation of the ileal mucous membrane microbiome.Jiajun YangJing WangKehe HuangQingxin LiuGuofangLiuXiaozhou XuHao ZhangMengling ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiajun Yang Jing Wang Kehe Huang Qingxin Liu GuofangLiu Xiaozhou Xu Hao Zhang Mengling Zhu Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition
description	Abstract Here, a Selenium-enriched Bacillus subtilis (SEBS) strain was generated and supplemented to broiler chickens’ diet, and the impact in ileum bacterial microbiome, immunity and body weight were assessed. In a nutshell, five hundred 1-old old chicken were randomly divided into five groups: control, inorganic Se, Bacillus subtilis (B. subtilis), SEBS, and antibiotic, and colonization with B. subtilis and SEBS in the gastrointestinal tract (GIT) were measured by fluorescence in situ hybridization (FISH) assay and quantitative real-time polymerase chain reaction (qPCR). In summary, Chicks fed SEBS or B. subtilis had higher body weight than the control chicks or those given inorganic Se. SEBS colonized in distal segments of the ileum improved bacterial diversity, reduced the endogenous pathogen burden and increased the number of Lactobacillus sp. in the ileal mucous membrane. Species of unclassified Lachnospiraceae, uncultured Anaerosporobacter, Peptococcus, Lactobacillus salivarius, and Ruminococcaceae_UCG-014, and unclassified Butyricicoccus in the ileal mucous membrane played a key role in promoting immunity. Inorganic Se supplementation also improved bacterial composition of ileal mucous membranes, but to a less extent. In conclusion, SEBS improved performance and immunity of broiler chickens through colonization and modulation of the ileal mucous membrane microbiome.
format	article
author	Jiajun Yang Jing Wang Kehe Huang Qingxin Liu GuofangLiu Xiaozhou Xu Hao Zhang Mengling Zhu
author_facet	Jiajun Yang Jing Wang Kehe Huang Qingxin Liu GuofangLiu Xiaozhou Xu Hao Zhang Mengling Zhu
author_sort	Jiajun Yang
title	Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition
title_short	Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition
title_full	Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition
title_fullStr	Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition
title_full_unstemmed	Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition
title_sort	selenium-enriched bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ce2d748f7dde42e5885289cf8c2977ac
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Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition

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