LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

The induction of neuroendocrine differentiation occurs in enzalutamide treated castration resistant prostate cancer. Here, the authors show that lncRNA-21 mediates enzalutamide induced neuroendocrine differentiation through EZH2/STAT axis and EZH2 inhibition suppresses this differentiation.

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Autores principales:	Jie Luo, Keliang Wang, Shuyuan Yeh, Yin Sun, Liang Liang, Yao Xiao, Wanhai Xu, Yuanjie Niu, Liang Cheng, Sankar N. Maity, Runze Jiang, Chawnshang Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce2fec008477481fbe8be007e5be6a47
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spelling	oai:doaj.org-article:ce2fec008477481fbe8be007e5be6a472021-12-02T14:38:45ZLncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling10.1038/s41467-019-09784-92041-1723https://doaj.org/article/ce2fec008477481fbe8be007e5be6a472019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09784-9https://doaj.org/toc/2041-1723The induction of neuroendocrine differentiation occurs in enzalutamide treated castration resistant prostate cancer. Here, the authors show that lncRNA-21 mediates enzalutamide induced neuroendocrine differentiation through EZH2/STAT axis and EZH2 inhibition suppresses this differentiation.Jie LuoKeliang WangShuyuan YehYin SunLiang LiangYao XiaoWanhai XuYuanjie NiuLiang ChengSankar N. MaityRunze JiangChawnshang ChangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Luo Keliang Wang Shuyuan Yeh Yin Sun Liang Liang Yao Xiao Wanhai Xu Yuanjie Niu Liang Cheng Sankar N. Maity Runze Jiang Chawnshang Chang LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
description	The induction of neuroendocrine differentiation occurs in enzalutamide treated castration resistant prostate cancer. Here, the authors show that lncRNA-21 mediates enzalutamide induced neuroendocrine differentiation through EZH2/STAT axis and EZH2 inhibition suppresses this differentiation.
format	article
author	Jie Luo Keliang Wang Shuyuan Yeh Yin Sun Liang Liang Yao Xiao Wanhai Xu Yuanjie Niu Liang Cheng Sankar N. Maity Runze Jiang Chawnshang Chang
author_facet	Jie Luo Keliang Wang Shuyuan Yeh Yin Sun Liang Liang Yao Xiao Wanhai Xu Yuanjie Niu Liang Cheng Sankar N. Maity Runze Jiang Chawnshang Chang
author_sort	Jie Luo
title	LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
title_short	LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
title_full	LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
title_fullStr	LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
title_full_unstemmed	LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
title_sort	lncrna-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the ezh2/stat3 signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ce2fec008477481fbe8be007e5be6a47
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LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

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