LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

The induction of neuroendocrine differentiation occurs in enzalutamide treated castration resistant prostate cancer. Here, the authors show that lncRNA-21 mediates enzalutamide induced neuroendocrine differentiation through EZH2/STAT axis and EZH2 inhibition suppresses this differentiation.

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Autores principales: Jie Luo, Keliang Wang, Shuyuan Yeh, Yin Sun, Liang Liang, Yao Xiao, Wanhai Xu, Yuanjie Niu, Liang Cheng, Sankar N. Maity, Runze Jiang, Chawnshang Chang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/ce2fec008477481fbe8be007e5be6a47
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