Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice.

Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice.

Current treatments for HBV chronic carriers using interferon alpha or nucleoside analogues are not effective in all patients and may induce the emergence of HBV resistant strains. Bay 41-4109, a member of the heteroaryldihydropyrimidine family, inhibits HBV replication by destabilizing capsid assemb...

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Autores principales: Nicolas Brezillon, Marie-Noëlle Brunelle, Hélène Massinet, Eric Giang, Céline Lamant, Lucie DaSilva, Sophie Berissi, Jacques Belghiti, Laurent Hannoun, Gherard Puerstinger, Eva Wimmer, Johan Neyts, Olivier Hantz, Patrick Soussan, Serban Morosan, Dina Kremsdorf
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/ce3067c018d44286925e45fb1cf480f7
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