Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex

Secreted class 3 semaphorins (Sema3s) form tripartite complexes with a plexin receptor and neuropilin co-receptor to transduce signals for neuronal axon guidance and other processes. Here, the authors present the cryo-EM structure of the extracellular Sema3A/PlexinA4/Neuropilin1 complex that provide...

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Autores principales:	Defen Lu, Guijun Shang, Xiaojing He, Xiao-chen Bai, Xuewu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce310e9dcd2d451c9abd91958660fde5
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spelling	oai:doaj.org-article:ce310e9dcd2d451c9abd91958660fde52021-12-02T14:42:19ZArchitecture of the Sema3A/PlexinA4/Neuropilin tripartite complex10.1038/s41467-021-23541-x2041-1723https://doaj.org/article/ce310e9dcd2d451c9abd91958660fde52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23541-xhttps://doaj.org/toc/2041-1723Secreted class 3 semaphorins (Sema3s) form tripartite complexes with a plexin receptor and neuropilin co-receptor to transduce signals for neuronal axon guidance and other processes. Here, the authors present the cryo-EM structure of the extracellular Sema3A/PlexinA4/Neuropilin1 complex that provides further insights into the interactions among semaphorin, plexin and neuropilin and reveals long flexible linkers in semaphorin and neuropilin that are important for complex formation.Defen LuGuijun ShangXiaojing HeXiao-chen BaiXuewu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Defen Lu Guijun Shang Xiaojing He Xiao-chen Bai Xuewu Zhang Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex
description	Secreted class 3 semaphorins (Sema3s) form tripartite complexes with a plexin receptor and neuropilin co-receptor to transduce signals for neuronal axon guidance and other processes. Here, the authors present the cryo-EM structure of the extracellular Sema3A/PlexinA4/Neuropilin1 complex that provides further insights into the interactions among semaphorin, plexin and neuropilin and reveals long flexible linkers in semaphorin and neuropilin that are important for complex formation.
format	article
author	Defen Lu Guijun Shang Xiaojing He Xiao-chen Bai Xuewu Zhang
author_facet	Defen Lu Guijun Shang Xiaojing He Xiao-chen Bai Xuewu Zhang
author_sort	Defen Lu
title	Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex
title_short	Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex
title_full	Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex
title_fullStr	Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex
title_full_unstemmed	Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex
title_sort	architecture of the sema3a/plexina4/neuropilin tripartite complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ce310e9dcd2d451c9abd91958660fde5
work_keys_str_mv	AT defenlu architectureofthesema3aplexina4neuropilintripartitecomplex AT guijunshang architectureofthesema3aplexina4neuropilintripartitecomplex AT xiaojinghe architectureofthesema3aplexina4neuropilintripartitecomplex AT xiaochenbai architectureofthesema3aplexina4neuropilintripartitecomplex AT xuewuzhang architectureofthesema3aplexina4neuropilintripartitecomplex
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Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex

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