Breast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study

Background Brain metastasis is an important cause of breast cancer-related death. Aim We evaluated the relationships between breast cancer subtype and prognosis among patients with brain metastasis at the initial diagnosis. Methods The Surveillance, Epidemiology, and End Results database was searche...

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Autores principales:	Dong-Jie He MM, De-Quan Yu MM, Qi-Ming Wang MM, Zong-Yan Yu MM, Yu-Hong Qi MD, Qiu-Ju Shao MM, Hao Chang MM
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ce31c0633f5147bebd5b5bc10ab84c52
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spelling	oai:doaj.org-article:ce31c0633f5147bebd5b5bc10ab84c522021-11-18T23:03:34ZBreast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study0046-95801945-724310.1177/00469580211055636https://doaj.org/article/ce31c0633f5147bebd5b5bc10ab84c522021-10-01T00:00:00Zhttps://doi.org/10.1177/00469580211055636https://doaj.org/toc/0046-9580https://doaj.org/toc/1945-7243Background Brain metastasis is an important cause of breast cancer-related death. Aim We evaluated the relationships between breast cancer subtype and prognosis among patients with brain metastasis at the initial diagnosis. Methods The Surveillance, Epidemiology, and End Results database was searched to identify patients with brain metastasis from breast cancer between 2010 and 2015. Multivariable Cox proportional hazard models were used to identify factors that were associated with survival among patients with initial brain metastases. The Kaplan–Meier method was used to compare survival outcomes according to breast cancer subtype. Results Among 752 breast cancer patients with brain metastasis at diagnosis, 140 patients (18.6%) underwent primary surgery and 612 patients (81.4%) did not undergo surgery, while 460 patients (61.2%) received chemotherapy and 292 patients (38.8%) did not receive chemotherapy. Multivariable analysis revealed that, relative to HR+/HER2– breast cancer, HR–/HER2– breast cancer was associated with significantly poorer overall survival (hazard ratio: 2.52, 95% confidence interval: 1.99–3.21), independent of age, sex, race, marital status, insurance status, grade, liver involvement, lung involvement, primary surgery, radiotherapy, and chemotherapy. The median overall survival intervals were 12 months for HR+/HER2−, 19 months for HR+/HER2+, 11 months for HR−/HER2+, and 6 months for HR–/HER2– ( P < .0001). Relative to HR+/HER2– breast cancer, HR–/HER2– breast cancer was associated with a significantly higher risk of mortality among patients, and the association was stronger among patients who received chemotherapy ( p for interaction = .005). Conclusions Breast cancer subtype significantly predicted overall survival among patients with brain metastasis at diagnosis.Dong-Jie He MMDe-Quan Yu MMQi-Ming Wang MMZong-Yan Yu MMYu-Hong Qi MDQiu-Ju Shao MMHao Chang MMSAGE PublishingarticlePublic aspects of medicineRA1-1270ENInquiry: The Journal of Health Care Organization, Provision, and Financing, Vol 58 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Public aspects of medicine RA1-1270
spellingShingle	Public aspects of medicine RA1-1270 Dong-Jie He MM De-Quan Yu MM Qi-Ming Wang MM Zong-Yan Yu MM Yu-Hong Qi MD Qiu-Ju Shao MM Hao Chang MM Breast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study
description	Background Brain metastasis is an important cause of breast cancer-related death. Aim We evaluated the relationships between breast cancer subtype and prognosis among patients with brain metastasis at the initial diagnosis. Methods The Surveillance, Epidemiology, and End Results database was searched to identify patients with brain metastasis from breast cancer between 2010 and 2015. Multivariable Cox proportional hazard models were used to identify factors that were associated with survival among patients with initial brain metastases. The Kaplan–Meier method was used to compare survival outcomes according to breast cancer subtype. Results Among 752 breast cancer patients with brain metastasis at diagnosis, 140 patients (18.6%) underwent primary surgery and 612 patients (81.4%) did not undergo surgery, while 460 patients (61.2%) received chemotherapy and 292 patients (38.8%) did not receive chemotherapy. Multivariable analysis revealed that, relative to HR+/HER2– breast cancer, HR–/HER2– breast cancer was associated with significantly poorer overall survival (hazard ratio: 2.52, 95% confidence interval: 1.99–3.21), independent of age, sex, race, marital status, insurance status, grade, liver involvement, lung involvement, primary surgery, radiotherapy, and chemotherapy. The median overall survival intervals were 12 months for HR+/HER2−, 19 months for HR+/HER2+, 11 months for HR−/HER2+, and 6 months for HR–/HER2– ( P < .0001). Relative to HR+/HER2– breast cancer, HR–/HER2– breast cancer was associated with a significantly higher risk of mortality among patients, and the association was stronger among patients who received chemotherapy ( p for interaction = .005). Conclusions Breast cancer subtype significantly predicted overall survival among patients with brain metastasis at diagnosis.
format	article
author	Dong-Jie He MM De-Quan Yu MM Qi-Ming Wang MM Zong-Yan Yu MM Yu-Hong Qi MD Qiu-Ju Shao MM Hao Chang MM
author_facet	Dong-Jie He MM De-Quan Yu MM Qi-Ming Wang MM Zong-Yan Yu MM Yu-Hong Qi MD Qiu-Ju Shao MM Hao Chang MM
author_sort	Dong-Jie He MM
title	Breast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study
title_short	Breast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study
title_full	Breast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study
title_fullStr	Breast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study
title_full_unstemmed	Breast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study
title_sort	breast cancer subtypes and mortality of breast cancer patients with brain metastasis at diagnosis: a population-based study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/ce31c0633f5147bebd5b5bc10ab84c52
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Breast Cancer Subtypes and Mortality of Breast Cancer Patients With Brain Metastasis at Diagnosis: A Population-Based Study

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