Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata

Kumutnart Chanprapaph, Thipprapai Mahasaksiri, Chaninan Kositkuljorn, Kanchana Leerunyakul, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatolog...

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Autores principales:	Chanprapaph K, Mahasaksiri T, Kositkuljorn C, Leerunyakul K, Suchonwanit P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	aa comorbidity hair loss non-scarring alopecia predictor systemic disorders Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ce32b8cb167b43a3bbe1932ab95a8778
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spelling	oai:doaj.org-article:ce32b8cb167b43a3bbe1932ab95a87782021-12-02T18:47:30ZPrevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata1178-7031https://doaj.org/article/ce32b8cb167b43a3bbe1932ab95a87782021-09-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-risk-factors-associated-with-the-occurrence-of-autoimmu-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Kumutnart Chanprapaph, Thipprapai Mahasaksiri, Chaninan Kositkuljorn, Kanchana Leerunyakul, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, ThailandTel +66-2-2011141Fax +66-2-201-1211 ext 4Email poonkiat@hotmail.comBackground: Increased rates of autoimmune diseases (ADs) have been reported in association with alopecia areata (AA); however, the risk factors for coexisting ADs in AA patients have been poorly investigated.Objective: To evaluate the prevalence and factors associated with AD comorbidities in patients with AA.Methods: This case–control study included patients diagnosed with AA between January 2000 and March 2020. Individuals with AA, both with and without concomitant ADs, were statistically compared. Variables significantly associated with coexisting ADs were identified using univariate and multivariate logistic regression analyses. Multinomial logistic regression analysis was performed to identify the specific risk factors for each concomitant AD.Results: Among the 615 patients with AA, comorbid ADs were found in 76 (12.4%). Autoimmune thyroid disease (AITD) exhibited the highest frequency (n = 42, 6.8%), followed by vitiligo (n = 15, 2.4%), and systemic lupus erythematosus (SLE) (n = 12, 2.0%). Logistic regression analyses revealed that female sex (odds ratio [OR] = 2.45, 95% confidence interval [CI] = 1.24– 4.82; P = 0.011), nail abnormalities (OR = 2.49, 95% CI = 1.14– 5.46; P = 0.023), and atopic diseases (OR = 1.98, 95% CI = 1.09– 2.43; P < 0.001) were significantly associated with coexisting ADs. Regarding each concomitant AD, nail abnormalities were an associated factor for AITD (OR = 4.65, 95% CI = 1.96– 7.24; P = 0.01), whereas coexisting atopic diseases were demonstrated as a predictor of vitiligo (OR = 2.48, 95% CI = 1.43– 4.58; P = 0.02). Female sex (OR = 1.61, 95% CI = 1.18– 4.27; P = 0.04) and family history of AD (OR = 1.85, 95% CI = 1.26– 4.19; P = 0.03) were predictors of SLE.Conclusion: This study suggests that female AA patients with nail abnormalities and atopic diseases have increased rates of AD comorbidities. A thorough review of systems for associated factors can help physicians screen for concomitant ADs.Keywords: AA, comorbidity, hair loss, non-scarring alopecia, predictor, systemic disordersChanprapaph KMahasaksiri TKositkuljorn CLeerunyakul KSuchonwanit PDove Medical Pressarticleaacomorbidityhair lossnon-scarring alopeciapredictorsystemic disordersPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 4881-4891 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aa comorbidity hair loss non-scarring alopecia predictor systemic disorders Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	aa comorbidity hair loss non-scarring alopecia predictor systemic disorders Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Chanprapaph K Mahasaksiri T Kositkuljorn C Leerunyakul K Suchonwanit P Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata
description	Kumutnart Chanprapaph, Thipprapai Mahasaksiri, Chaninan Kositkuljorn, Kanchana Leerunyakul, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, ThailandTel +66-2-2011141Fax +66-2-201-1211 ext 4Email poonkiat@hotmail.comBackground: Increased rates of autoimmune diseases (ADs) have been reported in association with alopecia areata (AA); however, the risk factors for coexisting ADs in AA patients have been poorly investigated.Objective: To evaluate the prevalence and factors associated with AD comorbidities in patients with AA.Methods: This case–control study included patients diagnosed with AA between January 2000 and March 2020. Individuals with AA, both with and without concomitant ADs, were statistically compared. Variables significantly associated with coexisting ADs were identified using univariate and multivariate logistic regression analyses. Multinomial logistic regression analysis was performed to identify the specific risk factors for each concomitant AD.Results: Among the 615 patients with AA, comorbid ADs were found in 76 (12.4%). Autoimmune thyroid disease (AITD) exhibited the highest frequency (n = 42, 6.8%), followed by vitiligo (n = 15, 2.4%), and systemic lupus erythematosus (SLE) (n = 12, 2.0%). Logistic regression analyses revealed that female sex (odds ratio [OR] = 2.45, 95% confidence interval [CI] = 1.24– 4.82; P = 0.011), nail abnormalities (OR = 2.49, 95% CI = 1.14– 5.46; P = 0.023), and atopic diseases (OR = 1.98, 95% CI = 1.09– 2.43; P < 0.001) were significantly associated with coexisting ADs. Regarding each concomitant AD, nail abnormalities were an associated factor for AITD (OR = 4.65, 95% CI = 1.96– 7.24; P = 0.01), whereas coexisting atopic diseases were demonstrated as a predictor of vitiligo (OR = 2.48, 95% CI = 1.43– 4.58; P = 0.02). Female sex (OR = 1.61, 95% CI = 1.18– 4.27; P = 0.04) and family history of AD (OR = 1.85, 95% CI = 1.26– 4.19; P = 0.03) were predictors of SLE.Conclusion: This study suggests that female AA patients with nail abnormalities and atopic diseases have increased rates of AD comorbidities. A thorough review of systems for associated factors can help physicians screen for concomitant ADs.Keywords: AA, comorbidity, hair loss, non-scarring alopecia, predictor, systemic disorders
format	article
author	Chanprapaph K Mahasaksiri T Kositkuljorn C Leerunyakul K Suchonwanit P
author_facet	Chanprapaph K Mahasaksiri T Kositkuljorn C Leerunyakul K Suchonwanit P
author_sort	Chanprapaph K
title	Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata
title_short	Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata
title_full	Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata
title_fullStr	Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata
title_full_unstemmed	Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata
title_sort	prevalence and risk factors associated with the occurrence of autoimmune diseases in patients with alopecia areata
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ce32b8cb167b43a3bbe1932ab95a8778
work_keys_str_mv	AT chanprapaphk prevalenceandriskfactorsassociatedwiththeoccurrenceofautoimmunediseasesinpatientswithalopeciaareata AT mahasaksirit prevalenceandriskfactorsassociatedwiththeoccurrenceofautoimmunediseasesinpatientswithalopeciaareata AT kositkuljornc prevalenceandriskfactorsassociatedwiththeoccurrenceofautoimmunediseasesinpatientswithalopeciaareata AT leerunyakulk prevalenceandriskfactorsassociatedwiththeoccurrenceofautoimmunediseasesinpatientswithalopeciaareata AT suchonwanitp prevalenceandriskfactorsassociatedwiththeoccurrenceofautoimmunediseasesinpatientswithalopeciaareata
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Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata

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