A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.

<h4>Background</h4>In the absence of an effective vaccine against HIV-1, the scientific community is presented with the challenge of developing alternative methods to curb its spread. Due to the complexity of the disease, however, our ability to predict the impact of various prevention a...

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Autores principales:	Lilit Yeghiazarian, William G Cumberland, Otto O Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce33a067f59b4a6da77e1c645b55d3f5
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spelling	oai:doaj.org-article:ce33a067f59b4a6da77e1c645b55d3f52021-11-18T08:44:45ZA stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.1932-620310.1371/journal.pone.0070578https://doaj.org/article/ce33a067f59b4a6da77e1c645b55d3f52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24302983/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In the absence of an effective vaccine against HIV-1, the scientific community is presented with the challenge of developing alternative methods to curb its spread. Due to the complexity of the disease, however, our ability to predict the impact of various prevention and treatment strategies is limited. While ART has been widely accepted as the gold standard of modern care, its timing is debated.<h4>Objectives</h4>To evaluate the impact of medical interventions at the level of individuals on the spread of infection across the whole population. Specifically, we investigate the impact of ART initiation timing on HIV-1 spread in an MSM (Men who have Sex with Men) population.<h4>Design and methods</h4>A stochastic multi-scale model of HIV-1 transmission that integrates within a single framework the in-host cellular dynamics and their outcomes, patient health states, and sexual contact networks. The model captures disease state and progression within individuals, and allows for simulation of therapeutic strategies.<h4>Results</h4>Early ART initiation may substantially affect disease spread through a population.<h4>Conclusions</h4>Our model provides a multi-scale, systems-based approach to evaluate the broader implications of therapeutic strategies.Lilit YeghiazarianWilliam G CumberlandOtto O YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e70578 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lilit Yeghiazarian William G Cumberland Otto O Yang A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.
description	<h4>Background</h4>In the absence of an effective vaccine against HIV-1, the scientific community is presented with the challenge of developing alternative methods to curb its spread. Due to the complexity of the disease, however, our ability to predict the impact of various prevention and treatment strategies is limited. While ART has been widely accepted as the gold standard of modern care, its timing is debated.<h4>Objectives</h4>To evaluate the impact of medical interventions at the level of individuals on the spread of infection across the whole population. Specifically, we investigate the impact of ART initiation timing on HIV-1 spread in an MSM (Men who have Sex with Men) population.<h4>Design and methods</h4>A stochastic multi-scale model of HIV-1 transmission that integrates within a single framework the in-host cellular dynamics and their outcomes, patient health states, and sexual contact networks. The model captures disease state and progression within individuals, and allows for simulation of therapeutic strategies.<h4>Results</h4>Early ART initiation may substantially affect disease spread through a population.<h4>Conclusions</h4>Our model provides a multi-scale, systems-based approach to evaluate the broader implications of therapeutic strategies.
format	article
author	Lilit Yeghiazarian William G Cumberland Otto O Yang
author_facet	Lilit Yeghiazarian William G Cumberland Otto O Yang
author_sort	Lilit Yeghiazarian
title	A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.
title_short	A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.
title_full	A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.
title_fullStr	A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.
title_full_unstemmed	A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.
title_sort	stochastic multi-scale model of hiv-1 transmission for decision-making: application to a msm population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ce33a067f59b4a6da77e1c645b55d3f5
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A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population.

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