Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study

Background: Clinical data on the relationship between triglycerides (TG)/HDL ratio and insulin resistance (IR) suggest that TG/HDL ratio may be a risk factor for IR. However, there is evidence that different races have different ri sk of developing IR. The relationship on TG/HDL ratio and IR in vari...

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Autores principales:	Rongpeng Gong, Gang Luo, Mingxiang Wang, Lingbo Ma, Shengnan Sun, Xiaoxing Wei
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	tg/hdl ratio insulin resistance association logistic regression subgroup analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doi.org/10.1530/EC-21-0414 https://doaj.org/article/ce38cbcbbb6a455790d68a144ad44907
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spelling	oai:doaj.org-article:ce38cbcbbb6a455790d68a144ad449072021-11-18T07:19:21ZAssociations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional studyhttps://doi.org/10.1530/EC-21-04142049-3614https://doaj.org/article/ce38cbcbbb6a455790d68a144ad449072021-11-01T00:00:00Zhttps://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0414.xmlhttps://doaj.org/toc/2049-3614Background: Clinical data on the relationship between triglycerides (TG)/HDL ratio and insulin resistance (IR) suggest that TG/HDL ratio may be a risk factor for IR. However, there is evidence that different races have different ri sk of developing IR. The relationship on TG/HDL ratio and IR in various populations needs to be improved. Therefore, we investigated whether TG/HDL ratio was linked to I R in different groups in the United States after controlling for other covariates. Methods: The current research was conducted in a cross-sectional manner. From 2009 to 2018, the National Health and Nutrition Examination Survey (NHANES) had a total of 49,696 participants, all of whom were Americans. The target-independent variable was TG/HDL ratio measured at baseline, and the dependent variable was IR. Additionally, the BMI, waist circumference, education, race, smoking, alcohol use, alanine transaminase, aspartate transaminase, and other covariates were also included in this analysis. Results: The average age of the 10,132 participants was 48.6 ± 18.4 years, and approximately 4936 (48.7%) were males. After correcting for confounders, fully adjusted logistic regression revealed that TG/HDL ratio was correlated w ith IR (odds ratio = 1.51, 95% CI 1.42–1.59). A nonlinear interaction between TG/HDL ratio and IR was discovered, with a point of 1.06. The impact sizes and CIs on the left and right sides of the inflection point were 6.28 (4.66–8.45) and 1.69 (1.45–1.97), respectively. According to subgroup analysis, the correlation was strong in females, alcohol users, and diabetes patients. Meanwhile, the inverse pattern was observed in the aged, obese, high-income, and smoking populations. Conclusion: In the American population, the TG/HDL ratio is positively associated with IR in a nonlinear interaction pattern. Rongpeng GongGang LuoMingxiang WangLingbo MaShengnan SunXiaoxing WeiBioscientificaarticletg/hdl ratioinsulin resistanceassociationlogistic regressionsubgroup analysisDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Connections, Vol 10, Iss 11, Pp 1502-1512 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tg/hdl ratio insulin resistance association logistic regression subgroup analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	tg/hdl ratio insulin resistance association logistic regression subgroup analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665 Rongpeng Gong Gang Luo Mingxiang Wang Lingbo Ma Shengnan Sun Xiaoxing Wei Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study
description	Background: Clinical data on the relationship between triglycerides (TG)/HDL ratio and insulin resistance (IR) suggest that TG/HDL ratio may be a risk factor for IR. However, there is evidence that different races have different ri sk of developing IR. The relationship on TG/HDL ratio and IR in various populations needs to be improved. Therefore, we investigated whether TG/HDL ratio was linked to I R in different groups in the United States after controlling for other covariates. Methods: The current research was conducted in a cross-sectional manner. From 2009 to 2018, the National Health and Nutrition Examination Survey (NHANES) had a total of 49,696 participants, all of whom were Americans. The target-independent variable was TG/HDL ratio measured at baseline, and the dependent variable was IR. Additionally, the BMI, waist circumference, education, race, smoking, alcohol use, alanine transaminase, aspartate transaminase, and other covariates were also included in this analysis. Results: The average age of the 10,132 participants was 48.6 ± 18.4 years, and approximately 4936 (48.7%) were males. After correcting for confounders, fully adjusted logistic regression revealed that TG/HDL ratio was correlated w ith IR (odds ratio = 1.51, 95% CI 1.42–1.59). A nonlinear interaction between TG/HDL ratio and IR was discovered, with a point of 1.06. The impact sizes and CIs on the left and right sides of the inflection point were 6.28 (4.66–8.45) and 1.69 (1.45–1.97), respectively. According to subgroup analysis, the correlation was strong in females, alcohol users, and diabetes patients. Meanwhile, the inverse pattern was observed in the aged, obese, high-income, and smoking populations. Conclusion: In the American population, the TG/HDL ratio is positively associated with IR in a nonlinear interaction pattern.
format	article
author	Rongpeng Gong Gang Luo Mingxiang Wang Lingbo Ma Shengnan Sun Xiaoxing Wei
author_facet	Rongpeng Gong Gang Luo Mingxiang Wang Lingbo Ma Shengnan Sun Xiaoxing Wei
author_sort	Rongpeng Gong
title	Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study
title_short	Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study
title_full	Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study
title_fullStr	Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study
title_full_unstemmed	Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study
title_sort	associations between tg/hdl ratio and insulin resistance in the us population: a cross-sectional study
publisher	Bioscientifica
publishDate	2021
url	https://doi.org/10.1530/EC-21-0414 https://doaj.org/article/ce38cbcbbb6a455790d68a144ad44907
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Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study

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