Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus

One of prominent pathogen associated with skin and surgical wound infections is Staphylococcus aureus, a Gram-positive skin normal flora. Severe infected open wound with bacterial colonisation would require intravenous antibiotics therapies and tortuous hospitalization procedures. Emerging bacterici...

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Autores principales:	G Ambarasan Govindasamy, Rabiatul Basria S. M. N. Mydin, Nor Hazliana Harun, Srimala Sreekantan
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Calotropis gigantea ZnO-CuO binary nanocomposites Bactericidal agents Open wound infection Skin infections Surgical wound infections Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5
Acceso en línea:	https://doaj.org/article/ce3b44cfbef644cda3a1c448ac009da1
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spelling	oai:doaj.org-article:ce3b44cfbef644cda3a1c448ac009da12021-11-30T04:17:17ZBactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus2589-299110.1016/j.mset.2021.08.013https://doaj.org/article/ce3b44cfbef644cda3a1c448ac009da12021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589299121000409https://doaj.org/toc/2589-2991One of prominent pathogen associated with skin and surgical wound infections is Staphylococcus aureus, a Gram-positive skin normal flora. Severe infected open wound with bacterial colonisation would require intravenous antibiotics therapies and tortuous hospitalization procedures. Emerging bactericidal agent with innovative nano-based green technology, may provide promising solution to tackle these issues. This study investigated the bactericidal potential of natural elements such as carbon and calcium decorated on ZnO–CuO nanocomposites synthesised from the medicinal plant Calotropis gigantea leaves. Dual-Ionic Honeycomb-like nanocomposites were produced at different calcination temperatures followed by characterization using x-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDS), UV–Visible spectrophotometer, atomic absorption spectroscopy (AAS). The bactericidal efficiency of ZnO–CuO nanocomposites on S.aureus greatly improved with dual-ionic systems (i.e. Cu2+ and Zn2+) especially the low temperature-calcined with minimum inhibitory concentration of 2.5 mg/mL, minimum bactericidal concentration of 20 mg/mL and zone of inhibition (ZOI) of 6.83 ± 0.29 mm at concentration of 10 mg/mL. These observations suggested that different calcination temperatures of ZnO–CuO nanocomposites may be initiated by the divergent and controlled ion distribution on ‘honeycomb’ porous structure, which was the underlying mechanism of killing effect towards S. aureus. Findings from this study may contribute knowledge to the development of a synergistic bactericidal agent with that could efficiently overcome bacterial colonisation associated with skin and surgical wound infections.G Ambarasan GovindasamyRabiatul Basria S. M. N. MydinNor Hazliana HarunSrimala SreekantanKeAi Communications Co., Ltd.articleCalotropis giganteaZnO-CuO binary nanocompositesBactericidal agentsOpen wound infectionSkin infectionsSurgical wound infectionsMaterials of engineering and construction. Mechanics of materialsTA401-492Energy conservationTJ163.26-163.5ENMaterials Science for Energy Technologies, Vol 4, Iss , Pp 383-390 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Calotropis gigantea ZnO-CuO binary nanocomposites Bactericidal agents Open wound infection Skin infections Surgical wound infections Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5
spellingShingle	Calotropis gigantea ZnO-CuO binary nanocomposites Bactericidal agents Open wound infection Skin infections Surgical wound infections Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5 G Ambarasan Govindasamy Rabiatul Basria S. M. N. Mydin Nor Hazliana Harun Srimala Sreekantan Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus
description	One of prominent pathogen associated with skin and surgical wound infections is Staphylococcus aureus, a Gram-positive skin normal flora. Severe infected open wound with bacterial colonisation would require intravenous antibiotics therapies and tortuous hospitalization procedures. Emerging bactericidal agent with innovative nano-based green technology, may provide promising solution to tackle these issues. This study investigated the bactericidal potential of natural elements such as carbon and calcium decorated on ZnO–CuO nanocomposites synthesised from the medicinal plant Calotropis gigantea leaves. Dual-Ionic Honeycomb-like nanocomposites were produced at different calcination temperatures followed by characterization using x-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDS), UV–Visible spectrophotometer, atomic absorption spectroscopy (AAS). The bactericidal efficiency of ZnO–CuO nanocomposites on S.aureus greatly improved with dual-ionic systems (i.e. Cu2+ and Zn2+) especially the low temperature-calcined with minimum inhibitory concentration of 2.5 mg/mL, minimum bactericidal concentration of 20 mg/mL and zone of inhibition (ZOI) of 6.83 ± 0.29 mm at concentration of 10 mg/mL. These observations suggested that different calcination temperatures of ZnO–CuO nanocomposites may be initiated by the divergent and controlled ion distribution on ‘honeycomb’ porous structure, which was the underlying mechanism of killing effect towards S. aureus. Findings from this study may contribute knowledge to the development of a synergistic bactericidal agent with that could efficiently overcome bacterial colonisation associated with skin and surgical wound infections.
format	article
author	G Ambarasan Govindasamy Rabiatul Basria S. M. N. Mydin Nor Hazliana Harun Srimala Sreekantan
author_facet	G Ambarasan Govindasamy Rabiatul Basria S. M. N. Mydin Nor Hazliana Harun Srimala Sreekantan
author_sort	G Ambarasan Govindasamy
title	Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus
title_short	Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus
title_full	Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus
title_fullStr	Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus
title_full_unstemmed	Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus
title_sort	bactericidal potential of dual-ionic honeycomb-like zno-cuo nanocomposites from calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: staphylococcus aureus
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/ce3b44cfbef644cda3a1c448ac009da1
work_keys_str_mv	AT gambarasangovindasamy bactericidalpotentialofdualionichoneycomblikeznocuonanocompositesfromcalotropisgiganteaagainstprominentpathogenassociatedwithskinandsurgicalwoundinfectionsstaphylococcusaureus AT rabiatulbasriasmnmydin bactericidalpotentialofdualionichoneycomblikeznocuonanocompositesfromcalotropisgiganteaagainstprominentpathogenassociatedwithskinandsurgicalwoundinfectionsstaphylococcusaureus AT norhazlianaharun bactericidalpotentialofdualionichoneycomblikeznocuonanocompositesfromcalotropisgiganteaagainstprominentpathogenassociatedwithskinandsurgicalwoundinfectionsstaphylococcusaureus AT srimalasreekantan bactericidalpotentialofdualionichoneycomblikeznocuonanocompositesfromcalotropisgiganteaagainstprominentpathogenassociatedwithskinandsurgicalwoundinfectionsstaphylococcusaureus
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Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus

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