INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA

Abstract. We have performed immunophenotyping of lymphocytes, employing a flow cytometry approach, along with evaluation of spontaneous or mitogen-induced production of cytokines (IFNγ, IL-4, IL-1β, IL - 10), in the patients with atopic and bacterial (mixed-type) bronchial asthma. We have detected m...

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Autores principales:	A. V. Zurochka, E. E. Dvorchik, S. V. Kvyatkovskaya, E. V. Shestakova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	lymphocytes cytokines immune status bronchial asthma Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ce3e5ad7338e48638223ec2aa413c27e
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spelling	oai:doaj.org-article:ce3e5ad7338e48638223ec2aa413c27e2021-11-18T08:03:40ZINVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2009-2-3-279-286https://doaj.org/article/ce3e5ad7338e48638223ec2aa413c27e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/322https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have performed immunophenotyping of lymphocytes, employing a flow cytometry approach, along with evaluation of spontaneous or mitogen-induced production of cytokines (IFNγ, IL-4, IL-1β, IL - 10), in the patients with atopic and bacterial (mixed-type) bronchial asthma. We have detected mostly similar changes in lymphocyte parameters. However, among the patients with bacterial asthma, an imbalance of immune cells was more pronounced. Some common alterations of cytokine production were found, i.e., a decrease in IFNγ and IL-1β production, along with increased IL-4 and IL-10. These changes were more significant in the subjects being in acute phase of either atopic, or bacterial asthma. Moreover, IL-10 suppressed IFNγ to higher degree, than IL-4, thus favoring distinct predomination of Th2-type immune response.A. V. ZurochkaE. E. DvorchikS. V. KvyatkovskayaE. V. ShestakovaSPb RAACIarticlelymphocytescytokinesimmune statusbronchial asthmaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 279-286 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocytes cytokines immune status bronchial asthma Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocytes cytokines immune status bronchial asthma Immunologic diseases. Allergy RC581-607 A. V. Zurochka E. E. Dvorchik S. V. Kvyatkovskaya E. V. Shestakova INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA
description	Abstract. We have performed immunophenotyping of lymphocytes, employing a flow cytometry approach, along with evaluation of spontaneous or mitogen-induced production of cytokines (IFNγ, IL-4, IL-1β, IL - 10), in the patients with atopic and bacterial (mixed-type) bronchial asthma. We have detected mostly similar changes in lymphocyte parameters. However, among the patients with bacterial asthma, an imbalance of immune cells was more pronounced. Some common alterations of cytokine production were found, i.e., a decrease in IFNγ and IL-1β production, along with increased IL-4 and IL-10. These changes were more significant in the subjects being in acute phase of either atopic, or bacterial asthma. Moreover, IL-10 suppressed IFNγ to higher degree, than IL-4, thus favoring distinct predomination of Th2-type immune response.
format	article
author	A. V. Zurochka E. E. Dvorchik S. V. Kvyatkovskaya E. V. Shestakova
author_facet	A. V. Zurochka E. E. Dvorchik S. V. Kvyatkovskaya E. V. Shestakova
author_sort	A. V. Zurochka
title	INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA
title_short	INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA
title_full	INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA
title_fullStr	INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA
title_full_unstemmed	INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA
title_sort	investigation of immune status and production cytokine in the patients with atopic and mixed-type bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ce3e5ad7338e48638223ec2aa413c27e
work_keys_str_mv	AT avzurochka investigationofimmunestatusandproductioncytokineinthepatientswithatopicandmixedtypebronchialasthma AT eedvorchik investigationofimmunestatusandproductioncytokineinthepatientswithatopicandmixedtypebronchialasthma AT svkvyatkovskaya investigationofimmunestatusandproductioncytokineinthepatientswithatopicandmixedtypebronchialasthma AT evshestakova investigationofimmunestatusandproductioncytokineinthepatientswithatopicandmixedtypebronchialasthma
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INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA

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