Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats

Abstract The effects of chronic antidepressant (AD) treatment on sleep disturbances in rodent chronic stress models have not been thoroughly investigated. Here, we show that chronic social defeat stress (SDS) in rats induces prolonged social avoidance, alterations in sleep architecture (increased to...

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Autores principales:	Yoshiki Matsuda, Nobuyuki Ozawa, Takiko Shinozaki, Kazuhisa Aoki, Naomi Nihonmatsu-Kikuchi, Toshikazu Shinba, Yoshitaka Tatebayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce44abf63a774cfbb1e4581a30ddcd01
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spelling	oai:doaj.org-article:ce44abf63a774cfbb1e4581a30ddcd012021-12-02T17:08:35ZChronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats10.1038/s41598-021-96094-02045-2322https://doaj.org/article/ce44abf63a774cfbb1e4581a30ddcd012021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96094-0https://doaj.org/toc/2045-2322Abstract The effects of chronic antidepressant (AD) treatment on sleep disturbances in rodent chronic stress models have not been thoroughly investigated. Here, we show that chronic social defeat stress (SDS) in rats induces prolonged social avoidance, alterations in sleep architecture (increased total rapid eye movement [REM] sleep duration, bout, and shortened REM latency), and contextual but not cued fear memory deficits, even 1 month after the last SDS. These abnormalities were associated with changes in electroencephalography (EEG) spectral powers, including reduced REM sleep theta power during the light phase. Chronic treatment with two different classes of antidepressants (ADs), imipramine and fluoxetine, significantly ameliorated these behavioral, sleep, and EEG abnormalities. Interestingly, REM theta power was normalized by chronic (1 month) but not 1 week AD administration and solely correlated with the ratio (an objective indicator) of social interaction 1 month after the last SDS. These data suggest that reductions in REM sleep theta power, an EEG parameter that has never been directly investigated in humans, is a core sleep symptom in socially defeated rats, and, potentially, also in patients with stress-related psychiatric disorders, including major depressive and posttraumatic stress disorders.Yoshiki MatsudaNobuyuki OzawaTakiko ShinozakiKazuhisa AokiNaomi Nihonmatsu-KikuchiToshikazu ShinbaYoshitaka TatebayashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshiki Matsuda Nobuyuki Ozawa Takiko Shinozaki Kazuhisa Aoki Naomi Nihonmatsu-Kikuchi Toshikazu Shinba Yoshitaka Tatebayashi Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats
description	Abstract The effects of chronic antidepressant (AD) treatment on sleep disturbances in rodent chronic stress models have not been thoroughly investigated. Here, we show that chronic social defeat stress (SDS) in rats induces prolonged social avoidance, alterations in sleep architecture (increased total rapid eye movement [REM] sleep duration, bout, and shortened REM latency), and contextual but not cued fear memory deficits, even 1 month after the last SDS. These abnormalities were associated with changes in electroencephalography (EEG) spectral powers, including reduced REM sleep theta power during the light phase. Chronic treatment with two different classes of antidepressants (ADs), imipramine and fluoxetine, significantly ameliorated these behavioral, sleep, and EEG abnormalities. Interestingly, REM theta power was normalized by chronic (1 month) but not 1 week AD administration and solely correlated with the ratio (an objective indicator) of social interaction 1 month after the last SDS. These data suggest that reductions in REM sleep theta power, an EEG parameter that has never been directly investigated in humans, is a core sleep symptom in socially defeated rats, and, potentially, also in patients with stress-related psychiatric disorders, including major depressive and posttraumatic stress disorders.
format	article
author	Yoshiki Matsuda Nobuyuki Ozawa Takiko Shinozaki Kazuhisa Aoki Naomi Nihonmatsu-Kikuchi Toshikazu Shinba Yoshitaka Tatebayashi
author_facet	Yoshiki Matsuda Nobuyuki Ozawa Takiko Shinozaki Kazuhisa Aoki Naomi Nihonmatsu-Kikuchi Toshikazu Shinba Yoshitaka Tatebayashi
author_sort	Yoshiki Matsuda
title	Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats
title_short	Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats
title_full	Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats
title_fullStr	Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats
title_full_unstemmed	Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats
title_sort	chronic antidepressant treatment rescues abnormally reduced rem sleep theta power in socially defeated rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ce44abf63a774cfbb1e4581a30ddcd01
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Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats

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