Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection

In crustaceans, the number of circulating hemocytes changes rapidly in response to pathogen infection and injury, but the underlying mechanism remains unclear. In this study, we investigated the regulation of hemocytes homeostasis in crayfish after hemolymph withdrawal. We showed that the circulatin...

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Autores principales:	Zaichao ZHENG, Fang LI, Hongyu LI, Kun ZHU, Limei XU, Feng YANG
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hemocyte homeostasis Sessile hemocyte Rapid regulation Gill White spot syndrome virus Zoology QL1-991
Acceso en línea:	https://doaj.org/article/ce4674659c1e4f6eaf35e84f3f9f759a
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spelling	oai:doaj.org-article:ce4674659c1e4f6eaf35e84f3f9f759a2021-11-28T04:39:41ZRapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection2667-011910.1016/j.fsirep.2021.100035https://doaj.org/article/ce4674659c1e4f6eaf35e84f3f9f759a2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S266701192100030Xhttps://doaj.org/toc/2667-0119In crustaceans, the number of circulating hemocytes changes rapidly in response to pathogen infection and injury, but the underlying mechanism remains unclear. In this study, we investigated the regulation of hemocytes homeostasis in crayfish after hemolymph withdrawal. We showed that the circulating hemocytes increased by over 2 folds within 1 h post hemolymph withdrawal and returned to normal level within 8 h. New hemocytes produced by hematopoiesis accounted for <6.5% of the total replenishment, implying a major role of sessile hemocytes in rapid hemocyte supply. Moreover, when hemocytes were transplanted, the extra cells were efficiently stored, mainly in the gill. These stored cells could be released into circulation immediately on demand. Notably, the rapid regulation of hemocyte homeostasis was abolished by white spot syndrome virus infection. These data indicate that the adjustment between the sessile and circulating pools of hemocytes may be the major route for the rapid regulation of circulating hemocytes in crayfish, and this process may be altered by pathogen infection.Zaichao ZHENGFang LIHongyu LIKun ZHULimei XUFeng YANGElsevierarticleHemocyte homeostasisSessile hemocyteRapid regulationGillWhite spot syndrome virusZoologyQL1-991ENFish and Shellfish Immunology Reports, Vol 2, Iss , Pp 100035- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hemocyte homeostasis Sessile hemocyte Rapid regulation Gill White spot syndrome virus Zoology QL1-991
spellingShingle	Hemocyte homeostasis Sessile hemocyte Rapid regulation Gill White spot syndrome virus Zoology QL1-991 Zaichao ZHENG Fang LI Hongyu LI Kun ZHU Limei XU Feng YANG Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection
description	In crustaceans, the number of circulating hemocytes changes rapidly in response to pathogen infection and injury, but the underlying mechanism remains unclear. In this study, we investigated the regulation of hemocytes homeostasis in crayfish after hemolymph withdrawal. We showed that the circulating hemocytes increased by over 2 folds within 1 h post hemolymph withdrawal and returned to normal level within 8 h. New hemocytes produced by hematopoiesis accounted for <6.5% of the total replenishment, implying a major role of sessile hemocytes in rapid hemocyte supply. Moreover, when hemocytes were transplanted, the extra cells were efficiently stored, mainly in the gill. These stored cells could be released into circulation immediately on demand. Notably, the rapid regulation of hemocyte homeostasis was abolished by white spot syndrome virus infection. These data indicate that the adjustment between the sessile and circulating pools of hemocytes may be the major route for the rapid regulation of circulating hemocytes in crayfish, and this process may be altered by pathogen infection.
format	article
author	Zaichao ZHENG Fang LI Hongyu LI Kun ZHU Limei XU Feng YANG
author_facet	Zaichao ZHENG Fang LI Hongyu LI Kun ZHU Limei XU Feng YANG
author_sort	Zaichao ZHENG
title	Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection
title_short	Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection
title_full	Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection
title_fullStr	Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection
title_full_unstemmed	Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection
title_sort	rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ce4674659c1e4f6eaf35e84f3f9f759a
work_keys_str_mv	AT zaichaozheng rapidregulationofhemocytehomeostasisincrayfishanditsmanipulationbyviralinfection AT fangli rapidregulationofhemocytehomeostasisincrayfishanditsmanipulationbyviralinfection AT hongyuli rapidregulationofhemocytehomeostasisincrayfishanditsmanipulationbyviralinfection AT kunzhu rapidregulationofhemocytehomeostasisincrayfishanditsmanipulationbyviralinfection AT limeixu rapidregulationofhemocytehomeostasisincrayfishanditsmanipulationbyviralinfection AT fengyang rapidregulationofhemocytehomeostasisincrayfishanditsmanipulationbyviralinfection
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Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection

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