Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis

Abstract Background Lymphedema, the accumulation of interstitial fluid caused by poor lymphatic drainage, is a progressive and permanent disease with no curative treatment. Several studies have evaluated cell-based therapies in secondary lymphedema, but no meta-analysis has been performed to assess...

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Autores principales:	Hector Lafuente, Ibon Jaunarena, Eukene Ansuategui, Arantza Lekuona, Ander Izeta
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Stem cells Lymphatic vasculature Lymphedema Regeneration Regenerative medicine Systematic review Medicine (General) R5-920 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/ce46e23cc8824a7db5073ff465a6cd69
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spelling	oai:doaj.org-article:ce46e23cc8824a7db5073ff465a6cd692021-11-21T12:04:44ZCell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis10.1186/s13287-021-02632-y1757-6512https://doaj.org/article/ce46e23cc8824a7db5073ff465a6cd692021-11-01T00:00:00Zhttps://doi.org/10.1186/s13287-021-02632-yhttps://doaj.org/toc/1757-6512Abstract Background Lymphedema, the accumulation of interstitial fluid caused by poor lymphatic drainage, is a progressive and permanent disease with no curative treatment. Several studies have evaluated cell-based therapies in secondary lymphedema, but no meta-analysis has been performed to assess their efficacy. Methods We conducted a systematic review and meta-analysis of all available preclinical and clinical studies, with assessment of their quality and risk of bias. Results A total of 20 articles using diverse cell types were selected for analysis, including six clinical trials and 14 pre-clinical studies in three species. The meta-analysis showed a positive effect of cell-based therapies on relevant disease outcomes (quantification of edema, density of lymphatic capillaries, evaluation of the lymphatic flow, and tissue fibrosis). No significant publication bias was observed. Conclusion Cell-based therapies have the potential to improve secondary lymphedema. The underlying mechanisms remain unclear. Due to relevant heterogeneity between studies, further randomized controlled and blinded studies are required to substantiate the use of these novel therapies in clinical practice.Hector LafuenteIbon JaunarenaEukene AnsuateguiArantza LekuonaAnder IzetaBMCarticleStem cellsLymphatic vasculatureLymphedemaRegenerationRegenerative medicineSystematic reviewMedicine (General)R5-920BiochemistryQD415-436ENStem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Stem cells Lymphatic vasculature Lymphedema Regeneration Regenerative medicine Systematic review Medicine (General) R5-920 Biochemistry QD415-436
spellingShingle	Stem cells Lymphatic vasculature Lymphedema Regeneration Regenerative medicine Systematic review Medicine (General) R5-920 Biochemistry QD415-436 Hector Lafuente Ibon Jaunarena Eukene Ansuategui Arantza Lekuona Ander Izeta Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis
description	Abstract Background Lymphedema, the accumulation of interstitial fluid caused by poor lymphatic drainage, is a progressive and permanent disease with no curative treatment. Several studies have evaluated cell-based therapies in secondary lymphedema, but no meta-analysis has been performed to assess their efficacy. Methods We conducted a systematic review and meta-analysis of all available preclinical and clinical studies, with assessment of their quality and risk of bias. Results A total of 20 articles using diverse cell types were selected for analysis, including six clinical trials and 14 pre-clinical studies in three species. The meta-analysis showed a positive effect of cell-based therapies on relevant disease outcomes (quantification of edema, density of lymphatic capillaries, evaluation of the lymphatic flow, and tissue fibrosis). No significant publication bias was observed. Conclusion Cell-based therapies have the potential to improve secondary lymphedema. The underlying mechanisms remain unclear. Due to relevant heterogeneity between studies, further randomized controlled and blinded studies are required to substantiate the use of these novel therapies in clinical practice.
format	article
author	Hector Lafuente Ibon Jaunarena Eukene Ansuategui Arantza Lekuona Ander Izeta
author_facet	Hector Lafuente Ibon Jaunarena Eukene Ansuategui Arantza Lekuona Ander Izeta
author_sort	Hector Lafuente
title	Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis
title_short	Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis
title_full	Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis
title_fullStr	Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis
title_full_unstemmed	Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis
title_sort	cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ce46e23cc8824a7db5073ff465a6cd69
work_keys_str_mv	AT hectorlafuente celltherapyasatreatmentofsecondarylymphedemaasystematicreviewandmetaanalysis AT ibonjaunarena celltherapyasatreatmentofsecondarylymphedemaasystematicreviewandmetaanalysis AT eukeneansuategui celltherapyasatreatmentofsecondarylymphedemaasystematicreviewandmetaanalysis AT arantzalekuona celltherapyasatreatmentofsecondarylymphedemaasystematicreviewandmetaanalysis AT anderizeta celltherapyasatreatmentofsecondarylymphedemaasystematicreviewandmetaanalysis
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Cell therapy as a treatment of secondary lymphedema: a systematic review and meta-analysis

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