Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull

Abstract Craniosynostosis, the premature fusion of cranial bones, affects the correct development of the skull producing morphological malformations in newborns. To assess the susceptibility of each craniofacial articulation to close prematurely, we used a network model of the skull to quantify the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Borja Esteve-Altava, Toni Vallès-Català, Roger Guimerà, Marta Sales-Pardo, Diego Rasskin-Gutman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce4d79c2f19e44d4b4f6d1731d2b26a1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ce4d79c2f19e44d4b4f6d1731d2b26a1
record_format	dspace
spelling	oai:doaj.org-article:ce4d79c2f19e44d4b4f6d1731d2b26a12021-12-02T16:06:28ZBone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull10.1038/s41598-017-03196-92045-2322https://doaj.org/article/ce4d79c2f19e44d4b4f6d1731d2b26a12017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03196-9https://doaj.org/toc/2045-2322Abstract Craniosynostosis, the premature fusion of cranial bones, affects the correct development of the skull producing morphological malformations in newborns. To assess the susceptibility of each craniofacial articulation to close prematurely, we used a network model of the skull to quantify the link reliability (an index based on stochastic block models and Bayesian inference) of each articulation. We show that, of the 93 human skull articulations at birth, the few articulations that are associated with non-syndromic craniosynostosis conditions have statistically significant lower reliability scores than the others. In a similar way, articulations that close during the normal postnatal development of the skull have also lower reliability scores than those articulations that persist through adult life. These results indicate a relationship between the architecture of the skull and the specific articulations that close during normal development as well as in pathological conditions. Our findings suggest that the topological arrangement of skull bones might act as a structural constraint, predisposing some articulations to closure, both in normal and pathological development, also affecting the long-term evolution of the skull.Borja Esteve-AltavaToni Vallès-CatalàRoger GuimeràMarta Sales-PardoDiego Rasskin-GutmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Borja Esteve-Altava Toni Vallès-Català Roger Guimerà Marta Sales-Pardo Diego Rasskin-Gutman Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull
description	Abstract Craniosynostosis, the premature fusion of cranial bones, affects the correct development of the skull producing morphological malformations in newborns. To assess the susceptibility of each craniofacial articulation to close prematurely, we used a network model of the skull to quantify the link reliability (an index based on stochastic block models and Bayesian inference) of each articulation. We show that, of the 93 human skull articulations at birth, the few articulations that are associated with non-syndromic craniosynostosis conditions have statistically significant lower reliability scores than the others. In a similar way, articulations that close during the normal postnatal development of the skull have also lower reliability scores than those articulations that persist through adult life. These results indicate a relationship between the architecture of the skull and the specific articulations that close during normal development as well as in pathological conditions. Our findings suggest that the topological arrangement of skull bones might act as a structural constraint, predisposing some articulations to closure, both in normal and pathological development, also affecting the long-term evolution of the skull.
format	article
author	Borja Esteve-Altava Toni Vallès-Català Roger Guimerà Marta Sales-Pardo Diego Rasskin-Gutman
author_facet	Borja Esteve-Altava Toni Vallès-Català Roger Guimerà Marta Sales-Pardo Diego Rasskin-Gutman
author_sort	Borja Esteve-Altava
title	Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull
title_short	Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull
title_full	Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull
title_fullStr	Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull
title_full_unstemmed	Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull
title_sort	bone fusion in normal and pathological development is constrained by the network architecture of the human skull
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ce4d79c2f19e44d4b4f6d1731d2b26a1
work_keys_str_mv	AT borjaestevealtava bonefusioninnormalandpathologicaldevelopmentisconstrainedbythenetworkarchitectureofthehumanskull AT tonivallescatala bonefusioninnormalandpathologicaldevelopmentisconstrainedbythenetworkarchitectureofthehumanskull AT rogerguimera bonefusioninnormalandpathologicaldevelopmentisconstrainedbythenetworkarchitectureofthehumanskull AT martasalespardo bonefusioninnormalandpathologicaldevelopmentisconstrainedbythenetworkarchitectureofthehumanskull AT diegorasskingutman bonefusioninnormalandpathologicaldevelopmentisconstrainedbythenetworkarchitectureofthehumanskull
_version_	1718384990651154432

Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull

Ejemplares similares