Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays.

Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays.

Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and counterpart normal DNA and noting regions where heterozygous alleles in the norma...

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Autores principales: Rameen Beroukhim, Ming Lin, Yuhyun Park, Ke Hao, Xiaojun Zhao, Levi A Garraway, Edward A Fox, Ephraim P Hochberg, Ingo K Mellinghoff, Matthias D Hofer, Aurelien Descazeaud, Mark A Rubin, Matthew Meyerson, Wing Hung Wong, William R Sellers, Cheng Li
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2006
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/ce4f67892b384292819d1424c67e2ab9
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