Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays.
Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and counterpart normal DNA and noting regions where heterozygous alleles in the norma...
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| Auteurs principaux: | , , , , , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2006
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/ce4f67892b384292819d1424c67e2ab9 |
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