Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays.

Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and counterpart normal DNA and noting regions where heterozygous alleles in the norma...

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Main Authors:	Rameen Beroukhim, Ming Lin, Yuhyun Park, Ke Hao, Xiaojun Zhao, Levi A Garraway, Edward A Fox, Ephraim P Hochberg, Ingo K Mellinghoff, Matthias D Hofer, Aurelien Descazeaud, Mark A Rubin, Matthew Meyerson, Wing Hung Wong, William R Sellers, Cheng Li
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2006
Subjects:	Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/ce4f67892b384292819d1424c67e2ab9
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https://doaj.org/article/ce4f67892b384292819d1424c67e2ab9

Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays.

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