Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings

Abstract Multisite, silicon-based probes are widely used tools to record the electrical activity of neuronal populations. Several physical features of these devices are designed to improve their recording performance. Here, our goal was to investigate whether the position of recording sites on the s...

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Autores principales:	Richárd Fiáth, Domokos Meszéna, Zoltán Somogyvári, Mihály Boda, Péter Barthó, Patrick Ruther, István Ulbert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce53f13b6643488783565aac41dc7d73
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spelling	oai:doaj.org-article:ce53f13b6643488783565aac41dc7d732021-12-02T15:23:29ZRecording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings10.1038/s41598-021-81127-52045-2322https://doaj.org/article/ce53f13b6643488783565aac41dc7d732021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81127-5https://doaj.org/toc/2045-2322Abstract Multisite, silicon-based probes are widely used tools to record the electrical activity of neuronal populations. Several physical features of these devices are designed to improve their recording performance. Here, our goal was to investigate whether the position of recording sites on the silicon shank might affect the quality of the recorded neural signal in acute experiments. Neural recordings obtained with five different types of high-density, single-shank, planar silicon probes from anesthetized rats were analyzed. Wideband data were filtered to extract spiking activity, then the amplitude distribution of samples and quantitative properties of the recorded brain activity (single unit yield, spike amplitude and isolation distance) were compared between sites located at different positions of the silicon shank, focusing particularly on edge and center sites. Edge sites outperformed center sites: for all five probe types there was a significant difference in the signal power computed from the amplitude distributions, and edge sites recorded significantly more large amplitude samples both in the positive and negative range. Although the single unit yield was similar between site positions, the difference in spike amplitudes was noticeable in the range corresponding to high-amplitude spikes. Furthermore, the advantage of edge sites slightly decreased with decreasing shank width. Our results might aid the design of novel neural implants in enhancing their recording performance by identifying more efficient recording site placements.Richárd FiáthDomokos MeszénaZoltán SomogyváriMihály BodaPéter BarthóPatrick RutherIstván UlbertNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Richárd Fiáth Domokos Meszéna Zoltán Somogyvári Mihály Boda Péter Barthó Patrick Ruther István Ulbert Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
description	Abstract Multisite, silicon-based probes are widely used tools to record the electrical activity of neuronal populations. Several physical features of these devices are designed to improve their recording performance. Here, our goal was to investigate whether the position of recording sites on the silicon shank might affect the quality of the recorded neural signal in acute experiments. Neural recordings obtained with five different types of high-density, single-shank, planar silicon probes from anesthetized rats were analyzed. Wideband data were filtered to extract spiking activity, then the amplitude distribution of samples and quantitative properties of the recorded brain activity (single unit yield, spike amplitude and isolation distance) were compared between sites located at different positions of the silicon shank, focusing particularly on edge and center sites. Edge sites outperformed center sites: for all five probe types there was a significant difference in the signal power computed from the amplitude distributions, and edge sites recorded significantly more large amplitude samples both in the positive and negative range. Although the single unit yield was similar between site positions, the difference in spike amplitudes was noticeable in the range corresponding to high-amplitude spikes. Furthermore, the advantage of edge sites slightly decreased with decreasing shank width. Our results might aid the design of novel neural implants in enhancing their recording performance by identifying more efficient recording site placements.
format	article
author	Richárd Fiáth Domokos Meszéna Zoltán Somogyvári Mihály Boda Péter Barthó Patrick Ruther István Ulbert
author_facet	Richárd Fiáth Domokos Meszéna Zoltán Somogyvári Mihály Boda Péter Barthó Patrick Ruther István Ulbert
author_sort	Richárd Fiáth
title	Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
title_short	Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
title_full	Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
title_fullStr	Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
title_full_unstemmed	Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
title_sort	recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ce53f13b6643488783565aac41dc7d73
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Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings

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